Maria Gaetana Agnesi – mathematician

Brilliant scholar gave her time and money to the poor

Maria Gaetana Agnesi learned
seven languages by the age of 11

Maria Gaetana Agnesi, the first woman to write a mathematics handbook, was born on this day in 1718 in Milan.

Maria became a mathematician, philosopher, theologian and humanitarian and was also the first woman to be appointed as a mathematics professor at a university.

She was one of at least 21 children born to Pietro Agnesi, a wealthy man whose family had made their money from silk production. Her mother was his first wife, Anna Fortunato Brivio, who was from a noble Milanese family.

Maria was soon recognised as a child prodigy, who could speak Italian and French by the time she was five and had learnt Greek, Hebrew, Spanish, German and Latin by the time she was 11.

When she became ill at the age of 12, it was thought to have been because of excessive studying and reading, but after she was prescribed vigorous dancing and horse riding to improve her health, she suffered convulsions and was then advised to moderate her activities.

By the time Maria was 14 she was studying ballistics and geometry. Her father regularly invited learned men to his house to listen to her read and to discuss philosophical questions with her.

The cover page of Agnesi's Instituzioni
 analitiche ad uso della gioventu italiana

After Maria’s mother died, her father remarried twice and Maria was given the task of teaching all her siblings and half-siblings.

This stopped her from fulfilling her wish to enter a convent.  Instead, her father agreed to let her live away from society and devote herself to the study of mathematics.

In 1740 she began studying differential and integral calculus with esteemed Italian mathematician Ramiro Rampinelli.

By 1748 Maria had published her Instituzioni analitiche ad uso della gioventù italiana. She said this was to give a systematic illustration of the different results and theorems of infinitesimal calculus. The work was translated into French and English and Maria received letters and gifts from the Habsburg Empress Maria Theresa and Pope Benedict XIV.

In the book, Maria discusses a curve that had been studied earlier by the mathematician Luigi Guido Grandi. He had called the curve ‘versoria,’ the Latin word for a rope that turns a sail, because that is what it reminded him of.  This was mistranslated as the word ‘witch’ in the English version and so the curve became known as ‘The Witch of Agnesi’.

The bust of  Agnesi at the
Palazzo di Brera in Milan

In 1750 Pope Benedict XIV appointed Maria to the chair of mathematics and natural philosophy and physics at Bologna University, although she never actually taught there. She was the second woman in the world to be granted a professorship at a university, Laura Bassi, an Italian physicist being the first.

After the death of her father in 1752, Maria finally had the chance to study theology. She then worked with the poor, sick and homeless, founding a home for the elderly in Milan, where she went to live.

In January 1799, Maria Gaetana Agnesi died at the age of 80. She was buried in a mass grave for the poor along with 15 other bodies.

An asteroid, 16765 Agnesi, a crater on Venus and a brandy are all named after her, as well as the mathematical curve, the Witch of Agnesi.

The Villa Agnesi Albertoni at Montevecchia in the province
of Lecco, where Maria and her family spent the summer

Travel tip:

You can visit the Villa Agnesi Albertoni, where Maria and her family spent time during the summer, which is in Largo Maria Gaetana Agnesi at Montevecchia in the province of Lecco, about 30 kilometres (19 miles) northeast of Milan. The villa has been preserved in the rococo style in which it was built during the 17th century. Visitors can still see the ‘salotto’, where eminent visitors would discuss philosophy with Maria Gaetana Agnesi and hear one of her sisters, Maria Teresa Agnesi play her own compositions on the harpsichord.

The famous Archiginnasio, the
university's anatomical theatre

Travel tip:

Bologna University, where Maria Gaetana Agnesi was the first woman to be appointed as a mathematics professor, was founded in 1088, making it the oldest university in the world. It attracted popes and kings as well as students of the calibre of Dante, Copernicus and Boccaccio. You can still visit one of the original university buildings in the centre of Bologna, the former anatomy theatre, the Archiginnasio, in Piazza Galvani. It is open Monday to Saturday from 9 am to 1 pm, admission free.

Also on this day:

1915: The birth of film director Mario Monicelli

1945: The birth of business tycoon Massimo Moratti

1974: The birth of singer-songwriter Laura Pausini


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Ascanio Sobrero - chemist

Professor who discovered nitroglycerine

Ascanio Sobrero discovered nitroglycerine during
an experiment in his laboratory at Turin University

The chemist Ascanio Sobrero, who discovered of the volatile compound that became known as nitroglycerine, was born on this day in 1812 in Casale Monferrato in Piedmont.

Nitroglycerine has a pharmaceutical use as a vasodilator, improving blood flow in the treatment of angina, but it is more widely known as the key ingredient in explosives such as dynamite and gelignite.

Its commercial potential was exploited not by Sobrero but by Alfred Nobel, the Swedish businessman and philanthropist who gave his name to the annually awarded Nobel Prizes.

Sobrero, aware of how much damage it could cause, had actually warned against nitroglycerine being used outside the laboratory.

Little is known about Sobrero’s early life, apart from his being born in Casale Monferrato, a town about 60km (37 miles) east of Turin.

He studied medicine in Turin and Paris and then chemistry at the University of Giessen in Germany, earning his doctorate in 1832. In 1845 he returned to the University of Turin, becoming a professor there.

Alfred Nobel, pictured at around the time he met
Sobrero in Paris in 1850

Sobrero had acquired some knowledge of explosives from the French chemist Théophile-Jules Pelouze, who had taught at the University of Turin while he was a student.

Around 1846 or 1847, during research, Sobrero experimented by adding glycerol to a mixture of concentrated nitric and sulfuric acids. The result was a colorless, oily liquid with a sweet, burning taste.

When he tried heating a drop in a test tube, it exploded. The fragments of glass scarred Sobrero’s face and hands. The liquid’s volatility frightened Sobrero so much that he told no one about it for more than a year. After he did finally announce his discovery, which he called pyroglycerine, he wrote to fellow chemists warning against its use, expanding on his misgivings in academic journals.

Nobel, whose family owned an armaments business in St Petersburg, had been, like Sobrero, a student at the University of Turin, albeit somewhat later.  They happened to meet in Paris in 1850.  On learning about Sobrero’s discovery, Nobel became interested in finding a way to control nitroglycerine’s explosive qualities.

It took him many years to achieve that ambition and there were mishaps along the way, not least in 1864, after the family had returned to Sweden from Russia, when an explosion at their factory in Heleneborg, Stockholm, killed five people, including Nobel's younger brother Emil. Undaunted, Nobel continued his work and in 1867 he obtained a patent as the inventor of dynamite. He went on to invent gelignite and ballistite, a predecessor of cordite.

The Nobel family business was still producing dynamite
to Alfred's patented formula in the 1930s

The inventions made Nobel’s fortune. He unfailingly acknowledged Sobrero as the man who had discovered nitroglycerine, although Sobrero sometimes claimed he was not given sufficient recognition.

At other times, by contrast, he gave the impression he would rather Nobel did not mention his name at all.  He was on record as saying: “When I think of all the victims killed during nitroglycerine explosions, and the terrible havoc that has been wreaked, which in all probability will continue to occur in the future, I am almost ashamed to admit to be its discoverer.”

Sobrero died in Turin in 1888, at the age of 75.  He is buried at the cemetery of Cavallermaggiore, about 40km (25 miles) south of Turin.

Piazza Mazzini in Casale Monferrato, which is named
after the revolutionary hero Giuseppe Mazzini

Travel tip:

Situated on the south bank of the Po river, Casale Monferrato is a town of some 36,000 inhabitants based on a former Roman city, later turned into a major citadel by the Gonzaga family. The historic centre is itself centred on Piazza Mazzini, the site of the Roman forum. The square is dominated by an 1843 equestrian statue by Abbondio Sangiorgio of King Charles Albert of Piedmont-Sardinia.  To the east of the square is the Lombard Romanesque cathedral of Sant'Evasio, founded in 742 and rebuilt in the early 12th century, occupying the site of a Roman temple dedicated to Jupiter.  See also the castle on Piazza Castello, a fortress that probably dates from 1000, built to a quadrilateral plan with corner towers and a moat.

An internal quadrangle at the University of Turin, where
Sobrero was a student and later a professor

Travel tip:

The University of Turin, where Sobrero studied and taught, is one of the oldest universities in Europe, founded in 1406 by Prince Ludovico di Savoia. It consistently ranks among the top five universities in Italy and is an important centre for research. The university departments are spread around 13 facilities, with the main university buildings in Via Giuseppe Verdi, close to Turin’s famous Mole Antonelliana.

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Bruno Pontecorvo - nuclear physicist

Defection to Soviet Union sparked unsolved mystery 

Bruno Pontecorvo hailed from a family
of talented individuals

Bruno Pontecorvo, a nuclear physicist whose defection to the Soviet Union in 1950 led to  suspicions of espionage after he had worked on research programmes in the United States, Canada, and the United Kingdom, was born on this day in 1913 in Marina di Pisa.

One of eight children born to Massimo Pontecorvo - a Jewish textile manufacturer who owned three factories - Bruno was from a family rich in intellectual talent. One of his brothers was the film director Gillo Pontecorvo, another the geneticist Guido Pontecorvo.

After high school, he enrolled at the University of Pisa to study engineering, but after two years switched to physics in 1931. He received a doctorate to study at the University of Rome La Sapienza, where Enrico Fermi had gathered together a group of promising young scientists, whom he dubbed “the Via Panisperna boys” after the name of the street where the Institute of Physics  was then situated.

Fermi described the 18-year-old Pontecorvo as one of the brightest young men he had met and invited Pontecorvo to work with him on his experiments bombarding atomic nuclei with slow neutrons.

Everything changed, however, after Benito Mussolini’s Fascist government passed a series of race laws, one of which excluded Jews from participating in higher education.

Enrico Fermi (above) rated Pontecorvo
as one of his brightest young scientists

Pontecorvo fled to Paris to work at the laboratory of Frédéric Joliot-Curie. During this period, influenced by his cousin, Emilio Sereni, he became a supporter of the ideals of communism and married Marianne Nordblom, a Swedish woman working in Paris as a nanny.

When Paris was invaded by the Germans in 1940, he became unsettled again.  He could not return to Italy and instead travelled to the United States, where Fermi had also gone. His new wife accompanied him.

In 1943 Pontecorvo joined the Anglo-Canadian nuclear research team at Chalk River, Ontario. There he worked on the design of the world’s first nuclear reactor using heavy water as a neutron moderator.

Despite earlier being seen as “undesirable”, in 1948 he was granted British citizenship. He joined the Atomic Energy Authority research station at Harwell, Berkshire, where classified research was being conducted.

Once Mussolini had been toppled, Pontecorvo had felt comfortable to begin taking holidays in Italy but during on such trip, in 1950, instead of returning to London, he and Marianne and their three children flew to Stockholm in Sweden and then on to Helsinki in Finland, at which point they disappeared.

Pontecorvo worked in France, the United States and
the United Kingdom before his defection in 1950

Ten months earlier, one of Pontecorvo’s colleagues at Harwell, Klaus Fuchs, confessed to spying for the Soviet Union - be was blamed by the US for Russia's development of nuclear weapons - and there was speculation that Pontecorvo had followed suit.

Pontecorvo’s relatives, including his sister, Anna, who lived in London, were at a loss to explain his disappearance, insisting he had given no indication that he was planning to fly from Rome to Stockholm.

Nothing was heard of him until 1955, when Pontecorvo appeared at a press conference in Moscow to promote the peaceful use of nuclear power. He denied ever having worked on nuclear weapons research.

Nonetheless, amid speculation that he and Fuchs and others had seriously endangered the West, he was stripped of his British passport. It has never been established why he left so abruptly and there is no concrete evidence that he was ever a spy. An alternative theory is that, because of his links with Fuchs - although they were not close friends - he was under surveillance by agents from America's FBI and feared for his safety if he remained in the West.

He would remain in the Soviet Union for the rest of his life, mainly at the Joint Institute for Nuclear Research (JINR) in Dubna, outside Moscow.

Pontecorvo received numerous awards for his work in Russia, including the Lenin Prize (1963) and the Order of Lenin (1983). After his death,  the JINR founded the annual Bruno Pontecorvo Prize to honour work done in particle physics. 

In accordance with his wishes, half of Pontecorvo's ashes were buried in the Protestant Cemetery in Rome, and another half in Dubna.

The yacht harbour at Marina di Pisa, the town where
the Pontecorvo family grew up

Travel tip:

Pisa used to be one of Italy’s major maritime powers, rivalling Genoa and Venice, until silt deposits from the Arno river gradually changed the landscape and ultimately cut the city off from the sea in the 15th century. Nowadays, almost 15km (9 miles) inland, it is a university city renowned for its art and architectural treasures, notably the Campo dei Miracoli, formerly known as Piazza del Duomo, located at the northwestern end of the city, which contains the cathedral (Duomo), baptistery and famously the tilting campanile known as the Leaning Tower of Pisa.  Marina di Pisa is situated where the Arno now meets the sea.  A popular seaside resort with a mix of sand and pebble beaches, it is home to the modern Port of Pisa yacht harbour.

The Via Panisperna (right) looking towards the Basilica di Santa
Maria Maggiore from the junction with Via Cesare Balbo

Travel tip:

The Via Panisperna is a Roman street that runs from Largo Angelicum, close to Trajan’s Forum and the Villa Aldobrandini in the direction of the Basilica di Santa Maria Maggiore. It forms part of the Rione Monti Roma district. It follows a straight, undulating path and crosses three of Rome’s seven hills - the Quirinale, the Viminale and the Esquilino.  The street is thought to take it name from the practice of the nearby convent of the Order of the Poor Clares for distributing “pane e perna” - bread and ham - among the local poor. The Church of San Lorenzo in Panisperna can reputedly trace its history to the reign of Emperor Constantine I in the early fourth century, only 100 years after the martyrdom of St Lawrence.

More reading:

Enrico Fermi - the Roman scientist who produced the world's first nuclear reactor

The first woman to head up Europe's major nuclear research body

Why Gillo Pontecorvo's most famous film was banned in France

Also on this day:

1599: The death of influential composer Luca Marenzio

1849: Austria launches world's first 'air raid' against Venice

1914: The death of Bishop Giacomo Radini-Tedeschi


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Giovanni Caselli - inventor

Priest and physicist who created world’s first ‘fax' machine

Although Caselli was ordained as a priest in
1836 he devoted his life to the study of science

Giovanni Caselli, a physics professor who invented the pantelegraph, the forerunner of the modern fax machine, was born on this day in 1815 in Siena.

Caselli developed a prototype pantelegraph, which was capable of transmitting handwriting and images over long distances via wire telegraph lines, in 1856, some 20 years ahead of the patenting of Alexander Graham Bell’s telephone in the United States. It entered commercial service in France in 1865.

The technology was patented in Europe and the United States in the 1860s, when it was also trialled in Great Britain and Russia, but ultimately in proved too unreliable to achieve universal acceptance and virtually disappeared from popular use until midway through the 20th century.

Caselli spent his early years in Florence studying physics, science, history and religion and was ordained as a priest in the Catholic Church when he was 21.

In 1841 he was appointed tutor to the sons of Count Marquis Sanvitale of Modena in Parma, where he spent eight years before his time there was abruptly ended by expulsion from the city as a result of his participation in an uprising against the ruling House of Austria-Este.

A model of Caselli's device can be seen
at the Leonardo da Vinci museum in Milan 

He returned to Florence in 1849, when he became a professor of physics at the University of Florence.  It was at this time that he began to study electrochemistry, electromagnetism, electricity and magnetism. He also launched a journal with the intention of explaining the science of physics in layman's terms.

Alexander Bain and Frederick Bakewell were two other physicists working on similar technology at the same time as Caselli but were unable to achieve the necessary synchronization between the transmitting and receiving parts so they would work together correctly. Caselli, though, built in a regulating clock that made the sending and receiving mechanisms work together.

In Caselli’s device, an image was made using non-conductive ink on tin foil, over which a stylus passed, lightly touching the foil, which conducted electricity where there was no ink and not where there was ink, causing circuit breaks that matched the image.

The signals were then sent along a long distance telegraph line to a receiver, where an electrical stylus reproduced the image line-by-line using blue dye ink on white paper.

In 1856, Caselli presented his prototype to Leopold II, Grand Duke of Tuscany, who was impressed enough to give Caselli some financial support, before he moved to Paris to introduce his invention to Napoleon III.

A 'fax' message that was transmitted between Paris and
Lyon using Caselli's pantelegraph in 1862

Napoleon embraced the technology with great enthusiasm, and between 1857 and 1861 Caselli worked on perfecting his pantelegraph, sometimes known as the Autotelegraph or Universal Telegraph, with the French mechanical engineer Léon Foucault.

After seeing a demonstration of Caselli's improved pantelegraph in 1860, Napoleon gave Caselli the chance to test in within the French national telegraph network, providing him with financial backing. Among the successful tests was one between Paris and Amiens, over a distance of 140km (87 miles) of a document bearing the signature of the composer Gioachino Rossini. 

After a further successful test between Paris and Marseille, commercial operations started in 1865, first between Paris and Lyon line, extending to Marseille in 1867.

After patenting his device in Europe in 1861 the United States in 1863, and receiving the Legion d’Honneur from Napoleon in recognition for his work, Caselli oversaw trials in England and Russia, where Tsar Alexander II used the system to send documents between his palaces in Saint Petersburg and Moscow between 1861 and 1865.

In the first year of operation, Caselli’s pantelegraph transmitted almost 5,000 'faxes'.

Yet Caselli could not develop the technology quickly enough for reliability issues to be solved and eventually interest in it began to decline to the extent that he effectively abandoned it and returned to Florence, where he died in 1891 at the age of 76.

Although in the 1920s, the AT & T Corporation developed a way to transmit images using radio signals, it was not until 1964 that the Xerox Corporation introduced the first commercial fax machine of the kind recognisable today.

Many of Caselli’s patents, letters and proofs of teleautographic transmission are kept at the municipal library of Siena. Others can be found in the archives of the Museo Galileo in Florence.

The shell-shaped Piazza del Campo in Siena is regarded
as one of the finest medieval squares in Europe

Travel tip: 

Siena, where Caselli was born, is famous for its shell-shaped Piazza del Campo, established in the 13th century as an open marketplace on a sloping site between the three communities that eventually merged to form Siena. It is regarded as one of Europe's finest medieval squares. The red brick paving, put down in 1349, fans out from the centre in nine sections. It has become well known as the scene of the historic horse race, the Palio di Siena.  Siena also has a beautiful Duomo - the Cathedral of St Mary of the Assumption - which was designed and completed between 1215 and 1263, its façade built in Tuscan Romanesque style using polychrome marble.

Piazza San Marco in Florence, a short distance from the centre
of the city, is the home of the University of Florence

Travel tip:

The University of Florence, the headquarters of which is in Piazza San Marco in the centre of the city, can trace its roots to the Studium Generale, which was established by the Florentine Republic in 1321. The Studium was recognized by Pope Clement VI in 1349, and included Italy’s first faculty of theology. The Studium became an imperial university in 1364, but was moved to Pisa in 1473 when Lorenzo the Magnificent gained control of Florence. Charles VIII moved it back from 1497–1515, but it was moved to Pisa again when the Medici family returned to power.  The modern university dates from 1859, when a group of institutions formed the Istituto di Studi Pratici e di Perfezionamento, which a year later was recognized as a full-fledged university, and renamed as the University of Florence in 1923.


More reading:

Antonio Meucci - the 'true' inventor of the telephone

Innocenzo Manzetti, the inventor who may have produced the first prototype telephone

The Italian physicist who pioneered the alternating current (AC) system

Also on this day:

Festa della Liberazione

1472: The death of Renaissance polymath Leon Battista Alberti

1973: The death of World War One flying ace Ferruccio Ranza

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Giuseppe Mercalli - seismologist

Giuseppe Mercalli became southern Europe's biggest
authority on earthquakes and volcanic activity

Scientist who invented Mercalli Scale died in fire

The seismologist and volcanologist Giuseppe Mercalli, who at the time of his death was director of the Vesuvius Observatory, died in a fire at his home in Naples on this day in 1914.

The initial suspicion was that Mercalli, who devised a scale for determining the strength of earthquakes according to the intensity of shaking, had knocked over a paraffin lamp accidentally after falling asleep while working late.

However, an examination of his remains suggested by may have been strangled after disturbing an intruder, who then soaked his clothes in petrol before setting light to them. A sum of money worth the equivalent of $1,400 (€1,250) today was missing, although no one was ever apprehended for the crime.

Born in Milan, Mercalli was ordained a Roman Catholic priest and became a professor of Natural Sciences at the seminary of Milan, although he left under something of a cloud because of his support for Antonio Rosmini, a controversial priest and philosopher who campaigned for social justice and was fiercely critical of various aspects of how the Roman Catholic church operated.

Mercalli collecting data on the edge of the crater of Vesuvius,
with an aide on hand to keep him from falling

After he had left, the Italian government appointed him a professor at Domodossola in Piedmont, followed by a post at Reggio di Calabria. He was professor of geology at the University of Catania in the late 1880s and was given a post at the Naples University in 1892. He became director of the Vesuvius Observatory in 1911.

He is best remembered for the Mercalli intensity scale for measuring earthquakes which, in modified form, is still used today.

While studying seismic activity in Italy in the late 19th century, Mercalli’s access to seismic instrumentation was limited. Most of Mercalli's information came from personal accounts and observations of damage. To provide consistency in his analyses, he decided he needed a way to measure the relative effects of each event.

He first developed a scale with six degrees, with the most disastrous earthquakes given an intensity of six, but felt that this did not provide enough precision.  Another intensity scale called the deRossi-Forel scale that was gaining in prominence at the same time had the advantage of 10 degrees of intensity, although Mercalli felt it lacked meaningful description.

Mercalli was ordained as a priest before
beginning his scientific career

In 1902, Mercalli modified this 10-degree scale to include the detail he desired, and his new scale quickly caught on among European scientists

Mercalli also observed eruptions of the volcanoes Stromboli and Vulcano in the Aeolian Islands and his descriptions of these eruptions became the basis for two indices in the Volcanic Explosivity Index: 1 - Strombolian eruption, and 2 - Vulcanian eruption.

The scale has been tweaked by various other seismologists but remains the basis for determining an earthquake’s intensity. It is now known as the Modified Mercalli Intensity Scale.

Mercalli also engaged in detailed cataloguing of Italian earthquakes, which enabled him to produce a book - I vulcani e fénomeni vulcanici in Italia - which he used to assemble a clear picture of where most of the events happened.

Mercalli's work built his reputation across southern Europe, and he was often called upon to study events throughout the continent.  He travelled to Spain in 1884 to examine the aftermath of the Andalusian earthquake, and in 1887 Mercalli was the lead investigator of the deadly event in Imperia along the French and Italian Riviera.

He became famous even beyond scientific circles, to the extent that his death and the speculation over the circumstances was reported in the New York Times.

Some fascinating buildings line Piazza Mercato in the
medieval heart of Domodossola

Travel tip:

The name Domodossola is familiar to many Italian children as a line - ‘D’ is for Domodossola - recited in learning the alphabet at school. It is, in fact, a very pleasant town in northern Piedmont, close to the border with Switzerland and the last town at the Italian end of the Simplon Pass and the Simplon railway tunnel. Domodossola has a charming medieval centre around the Piazza Mercato, which has a number of interesting buildings. The Collegiale Church of Santi Gervasio and Protasio is the town’s most important church, while just outside the town is the Sacro Monte Calvario, a Roman Catholic sanctuary that is a UNESCO World Heritage site. The Palazzo Silva in Piazza Chiossi houses a civic museum. The area is surrounded by outstanding Alpine countryside, which can be admired from a light railway linking Domodossola and Locarno in Switzerland.

Domodossola hotels by Booking.com

The vast crater of Mount Vesuvius, which remains classified
as an active volcano despite being quiet since 1944

Travel tip:

The Vesuvius Observatory today is part of the Mount Vesuvius National Park, which was created in 1955. The crater of the volcano itself is accessible to visitors, albeit by guided tour only, and there is a road to within 200 metres of it, but after that the ascent is on foot only.  The crater is about 200 metres deep and has a maximum diameter of about 600 metres. The climb is said to be well worth it because the view takes in the entire coastline from the Gulf of Gaeta, some 84km (52 miles) to the north, to the Sorrento peninsula. Visitors can take the Naples-Sorrento line of the Circumvesuviana railway and get off at Ercolano station, from where a shuttle bus runs to the park. As well as the observatory, there is a museum, a visitor centre, a restaurant and a shop where you can buy Lacrima Christi del Vesuvio, the wine made from the grapes grown on the sloped of the volcano.

More reading:

1944 - the last Vesuvius eruption

How Italy's worst earthquake almost destroyed Messina and Reggio Calabria

The devastating quake that led to an architectural golden age

Also on this day:

1661: The birth of Venetian composer Francesco Gasparini, who gave Vivaldi a job

1923: The birth of cartoonist Benito Jacovitti

1943: The birth of politician Mario Monti, who was Italy’s prime minister from 2011 to 2013

(Picture credits: Mercalli on slopes of Vesuvius by Sailko; Domodossola by Little Joe; Vesuvius crater by S J Pinkney)

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Renato Dulbecco - Nobel Prize-winning physiologist

Research led to major breakthrough in knowledge of cancer

Renato Dulbecco emigrated to the United States
1946 after studying at the University of Turin

Renato Dulbecco, a physiologist who shared the 1975 Nobel Prize in Physiology or Medicine for his role in drawing a link between genetic mutations and cancer, was born on this day in 1914 in Catanzaro in Calabria.

Through a series of experiments that began in the late 1950s after he had emigrated to the United States, Dulbecco and two colleagues showed that certain viruses could insert their own genes into infected cells and trigger uncontrolled cell growth, a hallmark of cancer.

Their findings transformed the course of cancer research, laying the groundwork for the linking of several viruses to human cancers, including the human papilloma virus, which is responsible for most cervical cancers.

The discovery also provided the first tangible evidence that cancer was caused by genetic mutations, a breakthrough that changed the way scientists thought about cancer and the effects of carcinogens such as tobacco smoke.

Dulbecco, who shared the Nobel Prize with California Institute of Technology (Caltech) colleagues Howard Temin and David Baltimore, then examined how viruses use DNA to store their genetic information and, in his studies of breast cancer, pioneered a technique for identifying cancer cells by the proteins present on their surface.

Dulbecco found that viruses such as the human
papilloma virus could cause cell mutations

His proposal in 1986 to catalogue all human genes can be seen as the beginnings of the Human Genome Project, which was completed in 2003.

The son of a civil engineer, Dulbecco grew up in Liguria after his family moved from Catanzaro to the coastal city of Imperia. He graduated from high school at 16 and went on to the University of Turin, receiving his medical degree in 1936. He became friends there with two other future Nobel prizewinners, Rita Levi-Montalcini and Salvador Luria, who were fellow students.

Immediately upon graduating, he was required to do two years’ military service. He was discharged in 1938 but soon afterwards called up again as Italy entered the Second World War, joining the Italian Army as a medical officer.

His role eventually took him to the Russian front, where he suffered an injury to his shoulder that meant he was sent back to Italy to recuperate. Disillusioned with Mussolini and horrified at learning of the fate of Jews under Hitler, he decided not to return to the Army, joining the resistance instead. He stationed himself in a remote village outside Turin, tending to injured partisans.

After the war, he was briefly involved with politics, firstly on the Committee for National Liberation in Turin and then on the city council, but soon returned to Turin University to study physics and conduct biological research.

Dulbecco's fellow Turin University graduate
Salvador Duria also moved to America

With the encouragement of Levi-Montalcini, who would win a Nobel Prize in 1986 for her work in neurobiology, in 1946, he moved to United States, rejoining Luria, who shared a Nobel in 1969 for discoveries about the genetics of bacteria, at Indiana University, where they studied viruses. In the summer of 1949 he moved to Caltech, where he began his work on animal oncoviruses.

Dulbecco worked with Dr. Marguerite Vogt on a method of determining the amount of polio virus present in cell culture, a step that was vital in the development of polio vaccine, before becoming intrigued by a thesis written by Howard Temin on the connection between viruses and cancer.

He left Caltech in 1962 to move to the Salk Institute, a polio research facility in San Diego, and then in 1972 to the Imperial Cancer Research Fund (now Cancer Research UK) in London.

There was a mixed reaction in Italy when it was learned that ‘their’ Nobel Prize winner had become an American citizen. In fact, his Italian citizenship was revoked, although when he moved back to Italy in 1993 to spend four years as president of the Institute of Biomedical Technologies at National Council of Research in Milan he was made an honorary citizen.

Married twice, with three children, Dulbecco died in La Jolla, California, in 2012, three days before what would have been his 98th birthday.

From its elevated position, Catanzaro has views towards
the Ionian Sea and the resort of Catanzaro Lido

Travel tip:

Occupying a position 300m (980ft) above the Gulf of Squillace, Catanzaro is known as the City of the Two Seas because, from some vantage points, it is possible to see the Tyrrhenian Sea to the north of the long peninsula occupied by Calabria as well as the Ionian Sea to the south.  The historic centre, which sits at the highest point of the city, includes a 16th century cathedral built on the site of a 12th century Norman cathedral which, despite being virtually destroyed by bombing in 1943, has been impressively restored.  The city is about 15km (9 miles) from Catanzaro Lido, which has a long white beach typical of the Gulf of Squillace.

Hotels in Catanzaro by Booking.com

The waterfront of the Ligurian port city of Imperia, with
the Basilica of San Maurizio on top of the hill

Travel tip:

The beautiful city of Imperia, on Liguria's Riviera Poniente about 120km (75 miles) west of Genoa and 60km (37 miles) from the border with France, came into being in 1923 when the neighbouring ports of Porto Maurizio and Oneglia, either side of the Impero river, were merged along with several surrounding villages to form one conurbation.  Oneglia, once the property of the Doria family in the 13th century, has become well known for cultivating flowers and olives. Porto Maurizio, originally a Roman settlement called Portus Maurici, has a classical cathedral dedicated to San Maurizio, which was built by Gaetano Cantoni and completed in the early 19th century.

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More reading:

How Salvador Luria reached the United States after fleeing Paris on a bicycle

Grazia Deledda - the first Italian woman to win a Nobel Prize

The first physiologist to explain human movement

Also on this day:

1876: The birth of opera singer and director Giovanni Zenatello

1905: The birth of industrialist Enrico Piaggio

1921: The birth of actress Giulietta Masina

1990: The death of Autogrill pioneer Mario Pavesi

(Picture credits: Catanzaro view by Salvatore Migliari; Imperia waterfront by BMK)

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Giovanni Alfonso Borelli – physiologist and physicist

Neapolitan was the first to explain movement

Giovanni Alfonso Borelli was a
pioneer of biomechanics

The scientist who was the first to explain muscular movement according to the laws of statics and dynamics, Giovanni Alfonso Borelli, was born on this day in 1608 in Naples.

Borelli was also the first to suggest that comets travel in a parabolic path.

He was appointed professor of mathematics at Messina in 1649 and at Pisa in 1656. After 1675 he lived in Rome under the protection of Christina, the former Queen of Sweden. She had abdicated her throne in 1654, had converted to Catholicism and gone to live in Rome as the guest of the Pope.

Remembered as one of the most learned women of the 17th century, Christina became the protector of many artists, musicians and intellectuals who would visit her in the Palazzo Farnese, where she was allowed to live by the Pope.

Borelli’s best known work is De Motu Animalium - On the Movement of Animals - in which he sought to explain the movements of the animal body on mechanical principles. He is therefore the founder of the iatrophysical school. He dedicated this work to Queen Christina, who had funded it, but he died of pneumonia in 1679 before it was published.

A page from Borelli's De Motu
Animalium on arm movement

For this work he has become known as the father of modern biomechanics. The American Society of Biomechanics named its most prestigious award the Giovanni Borelli Award in 1984.

The award is given to scientists for the originality, quality and depth of their research, and its relevance to the field of biomechanics.

Borelli also wrote astronomical works, including a treatise in 1666 that considered the influence of attraction on the satellites of Jupiter.  In a letter published in 1665, using the pseudonym Pier Maria Mutoli, he was the first to suggest the idea that comets travel in a parabolic path.

The Castel Nuovo in Naples, built in the 13th century
and rebuilt by Alfonso I in 1453

Travel tip:

Borelli was born in the Castel Nuovo area of Naples to a Spanish infantryman serving in the city and a young Neapolitan girl. The castle was called ‘nuovo’, new, when it was built in the 13th century to distinguish it from two earlier ones in Naples, Castel d’Ovo and Castel Capuano. Alfonso I, King of Naples and Sicily, had it completely rebuilt in 1453, the year of his triumphant entry into Naples. Alfonso later ordered the construction of the superb Arco di Trionfo, one of the most significant expressions of early Renaissance culture in southern Italy.

The Palazzo Farnese in Rome, once home of the former
Queen Christina of Sweden, now houses the French embassy

Travel tip:

Palazzo Farnese, where Borelli would visit his patron, Queen Christina, is one of the most important High Renaissance palaces in Rome. Owned by the Italian republic, the palazzo in Piazza Farnese was given to the French Government in 1936 for a period of 99 years and currently serves as the French embassy in Italy. One of the scenes in Puccini’s opera Tosca is set in Palazzo Farnese.

More reading:

The physicist who inspired Mary Shelley's Frankenstein

The 18th century anatomist who turned pathology into a science

The scientist who gave new 'life' to a dead frog and a new word to the language

Also on this day:

1453: The birth of Renaissance beauty Simonetta Vespucci

1813: The birth of scientist Paolo Gorini

1978: The birth of goalkeeper Gianluigi Buffon


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Rafael Bombelli – mathematician

First person to explain algebra in simple language

The front cover of the 1579 edition of
Bombelli's text, published in Bologna

Rafael Bombelli, the mathematician regarded as the inventor of complex numbers, was baptised and was also probably born on this day in 1526 near Bologna.

He wrote a book about algebra in simple language that could be understood by everyone, giving a comprehensive account of what was known about the subject at the time. The first three volumes, published in 1572, were the first European texts to explain how to perform computations with negative numbers.

Rafael Bombelli was the eldest son of Antonio Mazzoli, a wool merchant, who had changed his name to Bombelli to disassociate himself from the reputation of his family. His grandfather had taken part in a failed attempt to seize Bologna on behalf of the Bentivoglio family but had been caught and executed. Antonio Mazzoli was able to return to Bologna only after changing his name to Bombelli.

It is thought that Rafael Bombelli did not attend university but was taught by an engineer-architect named Pier Francesco Clementi.

He followed Clementi into the profession and acquired a patron, Alessandro Rufini. His patron was given the right to reclaim marsh land in the Val di Chiana by the Pope and Bombelli worked on this project until 1555 when there was an interruption to the reclamation work.

Bombelli wrote his algebra book while staying in
his patron's villa in Frascati, outside Rome

While he was waiting for the project to start again he decided to write an algebra book, while living in the comfortable surroundings of his patron’s villa just outside Rome in Frascati.

He felt that the reason for arguments between mathematicians was the lack of a careful exposition of the subject. The only books about algebra were not accessible to people without a thorough grasp of mathematics and he deliberately used simple language to make the book available to people who had not received higher education.

He died in Rome in 1572, soon after the first three volumes of the book were published. The unfinished manuscript of the other two volumes was discovered in a library in Bologna in 1923 and published in 1929.

Despite the delay in publication, Bombelli’s Algebra was a very influential work and was praised by later mathematicians because his analysis of the subject showed him to be far ahead of his time.

A crater on the moon has been named the Bombelli crater in honour of him.

The church of Santa Maria Assunta in Borgo Panigale

Travel tip:

Bombelli’s family lived in Borgo Panigale, a small town to the north of Bologna, which was annexed to the city by the Fascist government in 1937. It is now home to Bologna’s Guglielmo Marconi airport and the motorbike manufacturer Ducati. The Bologna artist Elisabetta Sirani painted an altarpiece for the parish church of Borgo Panigale. It is thought the name stems in part from the land around the site of the town, which was formerly used for the cultivation of the foxtail millet cereal called panìco in Italian.

The facade of the Villa Falconieri in
Frascati, where Bombelli stayed

Travel tip:

The Villa Falconieri in Frascati, to the south of Rome, was originally called Villa Rufina, having been built for Alessandro Rufini in 1546. It was while staying in this villa that Bombelli wrote his famous work on Algebra, which he dedicated to his patron, Rufini. The villa, which was renovated by the leading Roman Baroque architect Francesco Borromini after it was sold in 1628, houses many beautiful frescoes and is surrounded by splendid Italian gardens with a small lake bordered by cypresses. Now the headquarters of the Vivarium Novum Latin and Humanities Academy, it is open to the public from 10am to 1pm each Sunday.

More reading:

The mathematician who turned down Peter the Great of Russia

The maths professor who won the equivalent of a Nobel Prize at just 34

The mathematician and scientist who discovered the secret of embalming

Also on this day:

1920: The birth of filmmaker Federico Fellini

1950: The birth of former Vogue editor Franca Sozzani

1987: The birth of motorcycle racer Marco Simoncelli


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Caterina Scarpellini – astronomer and meteorologist

Female ‘assistant’ remembered for her important discoveries

Caterina Scarpellini moved to work at
Campidoglio Observatory aged 18

The astronomer Caterina Scarpellini, who discovered a comet in 1854 and was later awarded a medal by the Italian government for her contribution to the understanding of astronomy and other areas of science, died on this day in 1873 in Rome.

Caterina had moved from her native Foligno in Umbria to Rome at the age of 18 to work as an assistant to her uncle, Abbe Feliciano Scarpellini, who was the director of the Roman Campidoglio Observatory. He had been appointed in 1816 by Pope Pius VI to a new chair of sacred physics in the Roman College of the Campidoglio, marking a turning point in the attitude of the Roman Catholic Church to science.

From 1847 onwards, Caterina edited Corrispondenza Scientifica in Rome, a bulletin publishing scientific discoveries. She carried out her observations six times a day and reported on her findings.

The observatory was part of the Palazzo Senatorio on
Piazza del Campidoglio in the centre of Rome

She married Erasmo Fabri, who was also an assistant at the observatory, and together they established a meteorological station in Rome in 1856.

Caterina published reports of her astronomical observations and meteorological measurements in Italian, French and Belgian journals and also wrote about electrical, magnetic and geological phenomena.

Along with another scientist, she reported on a chemical analysis of sand that had fallen in Rome over three nights in February 1864, which she discovered had blown there from the Sahara desert during a storm.

She compiled the first Italian meteor catalogue and was the only observer in Rome of the 1866 Leonid meteor shower.

Caterina Scarpellini, here depicted in a magazine
illustration, made many important scientific findings

Caterina also wrote about Saturn’s rings, her ideas about the formation of the planets and her hypotheses concerning celestial mechanics.

She became a member of the Accademia dei Georgofili in Florence, an historic institution promoting scientific and agricultural research.

Her writings on the influence of the moon on earthquakes brought her honours from the Moscow Imperial Society of Naturalists and the Viennese Royal Geological Institute.

After Caterina’s death at the age of 65 following a stroke, a statue of her was erected in the Campo Verano cemetery in Rome. A crater on the planet Venus has been named after her.

The Palazzo Orfini in Foligno, where a printing shop
opened in 1470, printing Dante's Divine Comedy

Travel tip:

Foligno, where Caterina Scarpellini was born in 1808, is an ancient town in the province of Perugia in Umbria, situated 40km (25 miles) south east of Perugia. It has suffered several major earthquakes, including one as recently as 1997, but still standing are the 13th century Palazzo Communale and the Renaissance-style Palazzo Orfini, where a printing shop opened in 1470 and Dante’s Divine Comedy was printed there in 1472, becoming the first book to be printed in the Italian language.

The present-day Rome Observatory is in Villa di
Parco Mellini, at the top of Monte Mario

Travel tip:

The Campidoglio Observatory in Rome, where Caterina worked as assistant to her uncle, was located in the eastern tower of the Palazzo Senatorio in Piazza del Campidoglio on the top of Capitoline Hill. The observatory was later acquired by the Italian state and its equipment was transferred to the Villa di Parco Mellini at the top of Monte Mario outside Rome, which is still the location of the Astronomical Observatory of Rome and an Astronomical Museum housing an important collection of historic astronomical instruments.



More reading:

How 18th century scientist Laura Bassi broke new ground for women

Margherita Hack and the popularising of science

Why Giovanni Schiaparelli believed there were canals on Mars

Also on this day:

1907: The birth of writer Alberto Moravia

1913: The birth of film music composer Mario Nascimbene

1977: The birth of World Cup hero Fabio Grosso


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