Vittorio Erspamer - chemist
Professor who first identified the neurotransmitter serotonin
Vittorio Erspamer, the pharmacologist and chemist who first identified the neurotransmitter serotonin, was born on this day in 1909 in the small village of Val di Non in Malosco, a municipality of Trentino. Serotonin, also known as 5-hydroxytryptamine (5-HT), is found in the gastrointestinal tract, blood platelets and central nervous system of animals, including humans. It is popularly thought to be a contributor to feelings of well-being and happiness. A generation of anti-depressant drugs, including Prozac, Seroxat, Zoloft and Celexa, have been developed with the aim of interfering with the action of serotonin in the body in a way that boosts such feelings. The name serotonin was coined in the United States in 1948 after research doctors at the Cleveland Clinic in Ohio discovered a vasoconstrictor substance - one that narrows blood vessels - in blood serum. Since it was a serum agent affecting vascular tone, they named it serotonin. However, in 1952 it was shown that a substance identified by Dr Erspamer in 1935, which he named enteramine, was the same as serotonin. Dr Erspamer made his discovery when he was working as assistant professor in anatomy and physiology at the University of Pavia. Read more…
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Michelangelo Antonioni - film director
Enigmatic artist often remembered for 1966 movie Blowup
The movie director Michelangelo Antonioni, sometimes described as “the last great” of Italian cinema’s post-war golden era, died on this day in 2007 at his home in Rome. Antonioni, who was 94 years old when he passed away, was a contemporary of Federico Fellini and Luchino Visconti. Remarkably, three of that trio’s most acclaimed works - Fellini’s La dolce vita, Visconti’s Rocco and His Brothers and Antonioni’s L’avventura - appeared within a few months of one another. Antonioni’s genius lay in the way he challenged traditional approaches to storytelling and drama and the way people viewed the world in general. His characters were often intentionally vague, his most favoured themes being social alienation and bourgeois ennui, reflecting his view that life left many people emotionally adrift and unable to find their bearings. His movies often had no strong plot in a conventional sense, were dotted with unfinished conversations and seemingly disconnected incidents. His style was seen as a rejection of neorealism, his films more a metaphor for human experience, rather than a record of it. Read more…
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Naples earthquake of 1626
Devastating tremor and tsunami killed 70,000
The region around Naples, one of the most physically unstable areas of high population in the world with a long history of volcanic activity and earthquakes, suffered one of its more devastating events on this day in 1626. An earthquake that it has been estimated would register around seven on the modern Richter scale struck the city and the surrounding area. Its epicentre was about 50km out to sea, beyond the Bay of Naples and the island of Capri to the south, but the shock waves were strong enough to cause the collapse of many buildings in the city and the destruction of more than 30 small towns and villages. A tsunami followed, in which according to some reports the sea receded by more than three kilometres (two miles) before rushing back with enormous force, towering waves engulfing the coastline. In total, it is thought that approximately 70,000 people were killed by the quake itself and the tsunami. Naples at the time was a thriving city, still under Spanish rule. It had a population of around 300,000, which made it the largest port city in Europe and the second largest of all European cities apart from Paris. Read more…
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