Vittorio Erspamer - chemist

Professor who first identified the neurotransmitter serotonin

Dr Vittorio Erspamer

Vittorio Erspamer, the pharmacologist and chemist who first identified the neurotransmitter serotonin, was born on this day in 1909 in in the small village of Val di Non in Malosco, a municipality of Trentino.

Serotonin, also known as 5-hydroxytryptamine (5-HT), is found in the gastrointestinal tract, blood platelets and central nervous system of animals, including humans.

It is popularly thought to be a contributor to feelings of well-being and happiness. A generation of anti-depressant drugs, including Prozac, Seroxat, Zoloft and Celexa, have been developed with the aim of interfering with the action of serotonin in the body in a way that boosts such feelings.

The name serotonin was coined in the United States in 1948 after research doctors at the Cleveland Clinic in Ohio discovered a vasoconstrictor substance - one that narrows blood vessels - in blood serum. Since it was a serum agent affecting vascular tone, they named it serotonin.

However, in 1952 it was shown that a substance identified by Dr Erspamer in 1935, which he named enteramine, was the same as serotonin.

Dr Erspamer made his discovery when he was working as assistant professor in anatomy and physiology at the University of Pavia, having graduated there in medicine and surgery in 1935.

His speciality was pharmacognosy - the study of drugs from natural sources. In particular, he was interested in the extraction of pharmacologically active substances from animals, which was the focus of much of his life’s work.

An illustration of how scientists believe the dopamine and
serotonin neurotransmitters affect brain function

Dr Erspamer’s early research in the Institute of Comparative Anatomy and Physiology at Pavia focussed on the smooth muscle constricting or contracting properties of various compounds – known as amine - found in the skins and intestinal tracts of a number of species, including rabbits, mollusks, and frogs.

One substance which interested him was found in certain cells of the gut. An acetone isolate of the cells caused smooth muscle contraction, especially in the uterus of the female rat.

He carried out tests to prove that the substance was not another neurotransmitter, epinephrine - also known as adrenaline – and named the new substance enteramine.

During his career, Dr Erspamer held positions at the universities of Rome, Bari and Parma and also studied in Berlin.

The Ghislieri College at the University of Pavia, where
Vittorio Erspamer graduated and worked for several years

He was one of the first Italian pharmacologists to realize that strong relationships with the chemical and pharmaceutical industries could yield vital funds for research.

In the late 1950s, he established a long-term collaboration with chemists at the Farmitalia company, thanks to whose funding he collected more than 500 species of marine organisms from all around the world, including amphibians, shellfish, sea anemones and other species.

During more than 60 years he was able to conclude the isolation, identification, synthesis and pharmacological study of more than 60 new chemical compounds, most of which were isolated from animals, predominantly amphibians.

His other major discovery was octopamine, a substance similar in function to epinephrine in that it mobilises the body and the nervous system for action. He found this in the salivary glands of the octopus.

Twice nominated for a Nobel Prize, he was obliged to retire from official academic positions in 1984 on the grounds of age but continued to work at the Sapienza University of Rome, alongside his wife Giuliana Falconieri, a long-time colleague he married in the early 1960s, up until the time of his death in 1999 at the age of 90.

Malosco Castle, restored in the 16th century

Travel tip:

Vittorio Erspamer’s birthplace, Malosco, is a small village in the upper Val di Non valley situated on a high plateau about 54km (34 miles) north of Trento in an area of forests and meadows. The discovery of coins in the vicinity points to Roman origins. More recently, it belonged to the family of count Gerolamo Guarienti, who rebuilt Malosco Castle in the 16th century. Today it is a popular centre for cross-country skiing and there is a network of trails for walkers to enjoy.

Travel tip:

Although not established until 1361 – almost 300 years after the University of Bologna, which is recognised as the oldest in Europe – the University of Pavia can claim to have its roots in an educational institution in the Lombardy city of which the first known mention was in 825, in an edict issued by the Frankish king of Italy, Lothar I. That would make it older even than Al Quaraouyine University, in Morocco, which was founded in 859 and is officially the oldest continually operating educational institution in the world.

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Pope Urban VIII

Pontiff whose extravagance led to disgrace

Caravaggio's portrait of the future Urban VIII

The controversial Pope Urban VIII died on this day in 1644 in Rome.

Urban VIII – born Maffeo Barberini – was a significant patron of the arts, the sponsor of the brilliant sculptor and architect Gian Lorenzo Bernini, whose work had a major influence on the look of Rome.

But in his ambitions to strengthen and expand the Papal States, he overreached himself in a disastrous war against Odoardo Farnese, the Duke of Parma, and the expenses incurred in that and other conflicts, combined with extravagant spending on himself and his family, left the papacy seriously weakened.

Indeed, so unpopular was Urban VIII that after news spread of his death there was rioting in Rome and a bust of him on Capitoline Hill was destroyed by an angry mob.

His time in office was also notable for the conviction in 1633 for heresy of the physicist and astronomer Galileo Galilei, who had promoted the supposition, put forward by the Polish scientist Nicolaus Copernicus, that the earth revolved around the sun, which was directly contrary to the orthodox Roman Catholic belief that the sun revolved around the earth.

A bust of Urban VIII sculpted by
Gian Lorenzo Bernini in 1637-8

Urban VIII was born to Antonio Barberini, a Florentine nobleman, and Camilla Barbadoro, in Florence in April 1568, moving to Rome after the death of his father in 1571 to be placed in the charge of his uncle, Francesco Barberini, who was part of the papal staff.

He was educated by the Jesuits, received a doctorate of law from the University of Pisa and, through the influence of his uncle, was appointed by Pope Clement VIII to be a papal legate to the court of King Henry IV of France.

He became rich overnight at the death of his uncle, who had some years earlier named him as his heir. He immediately bought a palace in Rome that he turned into a luxurious Renaissance residence.

He maintained his high status in the church under Clement VIII’s successor, Pope Paul V, who raised him to the order of the Cardinal-Priest, with the titular church of San Pietro in Montorio. On the death of Paul V’s successor, Pope Gregory XV, he was chosen as pope in 1623.

Only 56 when he began he reign, he was seen as an elegant, refined figure with an aristocratic bearing and regarded as an excellent debater. He also was skilled in writing Latin verse and was the author of a number of hymns and scriptural works.

Yet he was extraordinarily extravagant and with shameless nepotism appointed several members of his family to prominent positions in the Roman Catholic hierarchy.

Gian Lorenzo Bernini took on many
commissions for Urban VIII

He elevated to Cardinal his brother Antonio Marcello Barberini and his nephews Francesco Barberini and Antonio Barberini. He also gave another nephew, Taddeo Barberini, the titles Prince of Palestrina, Gonfalonier of the Church, Prefect of Rome and Commander of Sant'Angelo.  The effect of this was that the wealth of the Barberini family grew massively.

Urban VIII’s sponsorship of Bernini was also extremely expensive, for all that it enriched the landscape of Rome for posterity.

In addition to having him sculpt several portrait busts of himself, Urban commissioned Bernini to work on the family palace in Rome, the Palazzo Barberini, the College of the Propaganda Fide and the Fontana del Tritone in the Piazza Barberini.

Urban appointed Bernini architect of St Peter’s in succession to Carlo Maderno. Many important additions were down to Bernini, including the gilt-bronze baldacchino over the tomb of St Peter and the colonnades enclosing the piazza in front of the basilica, which is considered his greatest architectural achievement.

Numerous members of the Barberini family also had their likenesses sculpted by Bernini, such as his brothers Carlo and Antonio. Urban also had Bernini rebuild the Church of Santa Bibiana and the Church of San Sebastiano al Palatino on the Palatine Hill.

Urban VIII’s spending extended to building the grandiose papal villa at Castel Gandolfo, fortifying the Castel Sant’Angelo in Rome, erecting the strategically located Fort Urbano at Castelfranco Emilia, near Modena, developing Civitavecchia, north of Rome, into a flourishing port with a military harbour, and enlarging the arsenal at Tivoli.

Bernini's Fontana del Tritone in Piazza Barberini
is one of the sculptor's many famous works in Rome

With the acquisition of the Duchy of Urbino in 1626, he had established the Papal States as a compact, well-defended bloc dominating central Italy.

But then came the war against Odoardo Farnese, the Duke of Parma, which some historians blame on his nephews.

The conflict was rooted in a quarrel over questions of etiquette during the Duke’s visit to Rome in 1639. In revenge,  the nephews persuaded Urban to ban the export of grain from Castro, an ancient city controlled by the Farnese family in what is now northern Lazio, to the Papal States.

This deprived Farnese of an income he needed to pay the interest on his borrowings. The Duke's creditors complained to the pope, who took forcible possession of Castro in order to assure the payment. When the Duke still failed to meet his debts, Urban excommunicated him and deprived him of all his fiefs.

What Urban VIII had not foreseen was that the Farnese would enlist the support of Tuscany, Modena, and Venice in raising an army of about 3000 horsemen, who put the papal troops to flight. When Urban refused to accept proposed peace terms, hostilities were renewed and continued until the pope finally conceded defeat in March, 1644.

By then the debts of the Papal States had grown so huge that 80 per cent of their annual income was spent on paying the interest alone.

Urban VIII died disliked and in disgrace, his achievements as pope, such as denouncing the slave trade in the West Indies and Brazil, clearing the way for Jesuit missionaries to travel to South America, China and Japan and banning the use of tobacco in holy places – a decree that was repealed 100 years later – not given the recognition they deserved.

His tomb, sculpted by Bernini, is in St Peter’s Basilica.

The papal palace at Castel Gandolfo opens on to the
town's main square, Piazza della Libertà

Travel tip:

Visitors to the town of Castel Gandolfo in the Alban Hills, overlooking Lago Albano in the area known as the Castelli Romani, can now go inside Urban VIII’s 17^th century papal palace, which ceased to be a papal residence in 2016 at the behest of the incumbent Pope Francis, ending its centuries’ old role as the summer retreat for the pontiff.  Built on the site of what was once the residence of the Roman emperor Domitian, the palace was designed for Urban VIII by the then architect of St Peter’s, Carlo Maderno.

Tortellini are said to be shaped to represent a female navel

Travel tip:

Castelfranco Emilia is a town just to the east of Modena, straddling the ancient Via Emilia, the Roman road that ran from Piacentia (now Piacenza) to Ariminum (now Rimini) on the Adriatic coast. It is said to be the home of tortellini, the stuffed pasta supposedly created by an innkeeper to represent the navel of a female guest with whom he was particularly taken and whom he had spied upon while bathing.

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Luigi Musso - racing driver

Wealthy Roman who found expectations hard to bear

Musso at the wheel of his Ferrari Formula One car

Luigi Musso, who for a period of his life was Italy’s top racing driver, was born on this day in 1924 in Rome.

Musso competed six times for the world drivers’ championship, three times for Maserati and three times for Ferrari. His finished third in the 1957 season, driving for Ferrari.

His solitary Formula One Grand Prix victory came in 1956 in Argentina, although he had to content himself with a half-share of the points after being forced to hand over his car to Juan Fangio, the local hero and Ferrari team leader, after 29 of the 98 laps, when Fangio’s car failed.

Sadly, two years later he was killed in an accident at the French Grand Prix in Reims, which his girlfriend, Fiamma Breschi, blamed on the ferocity of his rivalry with his fellow Ferrari drivers Mike Hawthorn and Peter Collins.

Born into a wealthy Roman family – his father was a diplomat – Musso grew up in a luxurious palazzo off the Via Veneto. He acquired his love of cars from his brothers, who were also racing drivers.

Luigi Musso was the wealthy son
of a Roman diplomat

He began to compete in 1950 in a car he bought himself, a 750cc Giannini sports car. He made an inauspicious start, his first race ending when he left the track and collided with a statue of the national hero, Giuseppe Garibaldi.

But he soon began to enjoy success racing sports cars and his talent was noted by Maserati, for whom he dominated the 1953 national 2000cc sports car championship. More success the following year, when he placed highly in the two big endurance road races, the Mille Miglia and the Targa Florio, as well as winning several smaller events, saw him named reserve driver for Maserati’s Formula One team. In that capacity he finished second in the Spanish Grand Prix in Barcelona.

He moved to Ferrari in 1956, a season which began with his handover to Fangio in Buenos Aires and was interrupted by a major crash in Germany, in which Musso was lucky to escape with only a broken arm.

When he returned for the Italian Grand Prix, the last race on the calendar, he found himself facing a repeat of the first, when his team asked him to surrender his car to Fangio.  This time, risking his Ferrari career, he refused, taking a gamble that almost paid off.  In the lead with four laps remaining, he suffered a puncture and then steering problems and was forced to quit, leaving Stirling Moss, in a Maserati, to win.

The pit lane at the Argentine Grand Prix of 1956, in which
Musso, whose car is No 12, gained his only F1 win

Musso was embarrassed. Yet far from attracting ignominy he endeared himself to the Monza crowd, who appreciated his daring.  Come the 1957 season he was firmly in the spotlight, the Italian press loving the new rivalry between Musso and his fellow Italian, Eugenio Castellotti.

When Castellotti suffered fatal injuries in a crash while testing, Italian motor racing fans looked to Musso more than ever to deliver success.

Yet he found the weight of expectation hard to bear.  He was now the best Italian driver, built up by the press as the heir to Alberto Ascari, the winner of back-to-back Formula One world titles in 1952 and 1953 but who had himself been killed in an accident in 1955.  The pressure on Musso to win races became intense.

There were rumours of debts, the result of a gambling habit that saw him lose large sums in the casinos. His personal life was in turmoil, too, after leaving his wife and two children for Fiamma, a beautiful blonde. And then there was the growing animosity between Musso and his Ferrari teammates, Hawthorn and Collins, two close friends who had a deal to pool their prize money and share it, from which Musso was excluded.

Musso's girlfriend, Fiamma Breschi

It all came to a head in the French Grand Prix at Reims in July. Musso was second on the grid behind Hawthorn, having matched his best-ever performance in practice. The race was the most lucrative on the calendar and Musso was determined to win.

Hawthorn made a flying start and began to pull away from the field.  Musso felt he had no option but to chase hard.  He took more and more risks until, on the 10^th lap, he took one too many.  Attempting to take a corner at 150mph, he was unable to keep the car on the track and one of the wheels clipped the edge of a ditch, sending it somersaulting into the air.

Musso was thrown from the car but suffered severe head injuries.  He was taken to hospital but died later that evening.

Breschi later recalled that after spending several hours at the hospital, doctors told her she should return to her hotel to rest. In the car park of the hotel she says she saw Hawthorn and Collins laughing and joking, playing football with a tin can, and hated them from that point onwards.

The Excelsior Hotel is a landmark on the Via Veneto

Travel tip:

The Via Vittorio Veneto, colloquially known as Via Veneto, is one of the most elegant and expensive streets in Rome. The street is named after the Battle of Vittorio Veneto (1918), a decisive Italian victory of the First World War. Federico Fellini's 1960 film La Dolce Vita was mostly centered on the Via Veneto area. Its bars and restaurants attracted Hollywood stars such as Audrey Hepburn, Anita Ekberg, Anna Magnani, Gary Cooper and Orson Welles as well as writers Tennessee Williams and Jean Cocteau and the designer Coco Chanel.

Monza Cathedral with its marble facade 

Travel tip:

Although widely known for its Formula One track, Monza has other attractions that tend to be overlooked. There is an elegant and stylish historical centre, in which the cathedral, which originated in the sixth century and was rebuilt in the 14^th, featuring a marble façade in Romanesque style with some Gothic adornments, and a bell tower added in 1606, stands out.  Another feature is the vast Parco di Monza, at 688 hectares one of the largest enclosed parks in Italy, which contains the Royal Villa, built between 1771 and 1780 for Archduke Ferdinand of Austria.

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Giosuè Carducci – poet and Nobel Prize winner

Writer used his poetry as a vehicle for his political views 

Giosuè Carducci in a photograph

 taken in about 1870

Giosuè Carducci, the first Italian to receive the Nobel Prize in Literature, was born on this day in 1835 in Tuscany.

Christened Giosuè Alessandro Giuseppe Carducci, he lived with his parents in the small village of Valdicastello in the province of Lucca.

His father, a doctor, was an advocate of the unification of Italy and was involved with the Carbonari, a network of secret revolutionary groups. Because of his politics, the family was forced to move several times during Carducci’s childhood, eventually settling in Florence.

During his time in college, Carducci became fascinated with the restrained style of Greek and Roman literature and his work as an adult often used the classical meters of such Latin poets as Horace and Virgil. He published his first collection of poems, Rime, in 1857.

He married Elvira Menicucci in 1859 and they had four children.

Carducci in around 1900

Carducci taught Greek at a high school in Pistoia and was then appointed as an Italian professor at the University of Bologna.

Carducci was a popular lecturer and a fierce critic of literature and society. He was an atheist, whose political views were vehemently hostile to Christianity generally and the Catholic Church in particular.

These opinions were voiced in a deliberately blasphemous and provocative poem, Inno a Satana - Hymn to Satan. This poem was published in Bologna’s radical newspaper, Il Popolo, at a time when feelings against the Vatican were running high and the public were pressing for an end to the Vatican’s domination over the papal states.

In 1890 Carducci met Annie Vivanti, a writer and poet with whom he had a love affair.

His greatest works have been judged to be his collections of poems, Rime Nuove (New Rhymes) and Odi Barbare (Barbarian Odes).

A bust of Carducci stands proud
in Castagneto Carducci

Carducci received the Nobel Prize in Literature in 1906 and was also made a Senator of Italy.

In the words of the citation, the award was made to Carducci "not only in consideration of his deep learning and critical research, but above all as a tribute to the creative energy, freshness of style, and lyrical force which characterize his poetic masterpieces"

The Nobel Prize in Literature has been awarded subsequently to five other Italians - Grazia Deledda, Luigi Pirandello, Salvatore Quasimodo, Eugenio Montale and Dario Fo.

During his life, Carducci wrote 20 volumes of literary criticism, biographies, speeches and essays.

He died in 1907 at the age of 71 in Casa Carducci, his home in Bologna and was buried in the Certosa di Bologna monumental cemetery.  His achievement is commemorated with busts and statues in public places in several Italian towns, including Castagneto Carducci, a hill town in the province of Livorno where he spent some years as a child.

Marina di Pietrasanta's beach is considered
to be in among the best in Italy

Travel tip:

Valdicastello, where Carducci was born, is part of Pietrasanta, a small town in the province of Lucca in the north-west corner of Tuscany. The town has Roman origins and part of the Roman wall still exists. The town is three kilometres (two miles) inland from the coastal resort of Marina di Pietrasanta. The Marina, with its golden sand, is considered to have one of the best beaches in Italy.

The Casa Carducci in Bologna houses the
Civic Museum of the Risorgimento

Travel tip:

Casa Carducci, where the poet lived until his death in 1907, is a 16th century villa in Piazza Giosuè Carducci in Bologna. The ground floor now houses the Civic Museum of the Risorgimento, which tells the story of the unification of Italy from a cultural, social and economic perspective. Visitors can also see Carducci’s bedroom, with the small granite washbasin he used, and the family dining room, which has a large clock with the hands stopped at the exact moment of the poet’s death. In his office there is a framed fragment of a tunic belonging to Petrarch and an armchair, where Garibaldi is said to have sat while he was recovering from an injury. The library contains about 40,000 books, pamphlets and documents, meticulously catalogued by Carducci himself.

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