Showing posts with label Medicine. Show all posts
Showing posts with label Medicine. Show all posts

28 November 2023

Umberto Veronesi - oncologist

Pioneered new techniques for treating breast cancer

Umberto Veronesi made an important contribution to breast cancer treatment
Umberto Veronesi made an important
contribution to breast cancer treatment 
Umberto Veronesi, an oncologist whose work in finding new methods to treat breast cancer spared many women faced with a full mastectomy, was born on this day in 1925 in Milan.

Along with many other contributions to the knowledge of breast cancer and breast cancer prevention over a 50-year career, Veronese was a pioneer of breast-conserving surgery in early breast cancer as an alternative to a radical mastectomy. 

He developed the technique of quadrantectomy, which limits surgical resection to the affected quarter of the breast. 

This more limited resection became standard practice for the treatment of breast cancer detected early after Veronesi led the first prospective randomised trial of breast-conserving surgery, which compared outcomes from radical mastectomy against his quadrantectomy over a 20-year period.

Veronesi supported and promoted research aimed at improving conservative surgical techniques in general and conducting studies on tamoxifen and retinoids which helped verify their effectiveness in preventing the formation of cancer in the first place. 

The founder and president of the Umberto Veronesi Foundation, he founded and held the role of scientific director and scientific director emeritus of the European Institute of Oncology, was scientific director of the National Cancer Institute of Milan and held the position of Minister of Health from April 2000 to June 2001 in the second government of prime minister Giuliano Amati.

Veronesi grew up in Casoretto, which was then an agricultural suburb of Milan, where his father was a tenant farmer.  He was one of six children. The family home was relatively remote, the only source of heat in the winter a fireplace in the kitchen. Going to school necessitated a 5km (three miles) walk to school and back, but his parents were determined that their five sons and a daughter would enjoy a good education.

Veronesi pictured at a book signing in 2013, still working at the age of 87
Veronesi pictured at a book signing in 2013, still
working at the age of 87
Veronesi’s father died when he was still a child but the memory of beatings handed out by Fascist squadristi meant that his father’s left-wing politics had a more profound effect on him than his mother’s devout Catholicism. He declared himself to be an agnostic at the age of 14.

He began to focus on cancer soon after graduating in medicine and surgery at the University of Milan in 1951 and specialising in surgery at the University of Pavia. He travelled to England and France to broaden his knowledge and joined the National Cancer Institute, of which he would become director-general in 1975, as a volunteer.

In the course of what would be a brilliant career, his far-sighted ideas were not well received initially and he had to fight to convince others.  Yet in time his scientific projects opened new boundaries in cancer treatment.  His belief in joining forces with patients, communicating with them clearly about their treatment and enlisting their help in campaigns to raise funds helped change attitudes towards the disease.

Veronesi too was instrumental in removing regulatory barriers in the management of terminal cancer patients, making opioid painkillers available to those whose cancer could not be cured.

Veronesi (right) with then president Giorgio Napolitano in 2011
Veronesi (right) with then president
Giorgio Napolitano in 2011
Away from the main focus of his life, Veronesi became politically active when the left-wing politician Bettino Craxi invited him to become a member of the national assembly of the Italian Socialist Party (PSI).  In April 2000 he was Minister of Health in the second Amato government, using his platform to campaign for an anti-smoking law.  He was later elected to the Senate as a member of the Democratic Party.

President of the Italian Nuclear Safety Agency from 2010-11, he resigned from that position in protest at the Berlusconi government for failing to provide the agency with even the minimum structures to carry out its activities.

He was a strong advocate of animal rights, believed in voluntary euthanasia and, controversially, supported the genetic modification of food because of its possibilities for helping parts of the world prone to crop failures and famine, and for removing naturally occurring carcinogens. 

His outspoken opposition to doctors’ strikes in the 1980s, however, caused him to fall foul of the Red Brigades, whose death threats left him looking over his shoulder in public for several years.

Veronesi died at home in November 2016 not long before what would have been his 91st birthday. After a secular funeral at Palazzo Marino, Milan’s city hall, where his son, Alberto, a conductor, led two musical pieces by Beethoven and Puccini, his body was cremated. 

Via Casoretto, looking towards the church of Santa Maria Bianca della Misericordia
Via Casoretto, looking towards the church of
Santa Maria Bianca della Misericordia
Travel tip:

The Casoretto of today is a neighbourhood in the northeastern suburbs of Milan, forming part of an area locally known as NoLo, an acronym for North of Loreto. The area is multicultural with a vibrant nightlife, art galleries and restaurants. Casoretto is notable for colourful houses and an unusually high number of cycle repair shops, reflecting local beliefs in eco-friendly travel.  The neighbourhood fans out from the central Via Casoretto and the church of Santa Maria Bianca della Misericordia, which is sometimes known as the Abbey of Casoretto. Until the start of the 20th century and industrialisation, the area was characterised by farmhouses and cultivated fields, with no significant residential areas apart from a few farmhouses and other buildings around the Abbey.


Palazzo Marino, with the entrace to the Galleria Vittorio Emanuele II to the right of the picture
Palazzo Marino, with the entrace to the Galleria
Vittorio Emanuele II to the right of the picture
Travel tip:

Palazzo Marino, where Veronesi’s secular funeral was held, is a 16th-century palace located in Piazza della Scala, in the centre of Milan. Standing opposite the world-famous opera house, Teatro alla Scala, and next to the northern entrance to the Galleria Vittorio Emanuele II, it has been Milan’s city hall since 1861. Designed by architect Galeazzo Alessi, it was built between 1557 and 1563 for Tommaso Marino, a wealthy Genovese banker and merchant.  After Marino died, leaving his family bankrupt, the palace became the property of the state before being sold to another banker, Carlo Omodei, who did not live there himself but rented it out to other notable Milanese, before reverting to state ownership in 1781. After being established as the seat of Milan’s municipal government in 1861, the palace was given a new facade to coincide with the creation of Piazza della Scala, undergoing a second major restoration after it was badly damaged by bombing in World War Two. 

Also on this day:

1873: The death of astronomer Caterina Scarpellini

1907: The birth of novelist Alberto Moravia

1913: The birth of composer Mario Nascembene

1941: The birth of actress Laura Antonelli

1955: The birth of footballer Alessandro Altobelli

1977: The birth of World Cup hero Fabio Grosso


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21 April 2022

Gino Strada - surgeon and charity founder

‘Maestro of humanity’ built hospitals for war victims

Gino Strada's charity has helped more than 11 million people worldwide
Gino Strada's charity has helped more
than 11 million people worldwide
The surgeon and founder of the medical and humanitarian charity Emergency, Gino Strada, was born on this day in 1948 in Sesto San Giovanni, a town that is now effectively a suburb of Milan.

Emergency has provided free healthcare to more than 11 million people in 19 different countries, including locations severely affected by conflict such as Afghanistan, Iraq, and Yemen.  It also operates in Eritrea, Sierra Leone, Uganda, Sudan, Cambodia, Serbia, Nicaragua and Sri Lanka.

The hospitals set up by the organisation - some designed with the help of Strada’s friend, the world-renowned architect Renzo Piano - are built to the highest standards, with the aim of providing world-class treatments and after-care. Strada, who was said himself to have performed more than 30,000 operations on direct or indirect victims of conflict, insisted that the hospitals in which his European volunteers worked had to be places where “you would be happy to have one of your family members treated”,

When Strada died in 2021, among the many tributes paid to him was one by the then president of the European parliament, David Sassoli, who described him as the ‘maestro of humanity’.

The son of a steelworker, Strada attended the Liceo Classico Giosuè Carducci, a high school specialising in science near Milano Centrale railway station. He then studied medicine and trauma surgery at the University of Milan, where he graduated in 1978, before training as a heart-lung transplant surgeon in the United States and South Africa.

The Emergency organisation's logo
The Emergency organisation's logo has become
a familiar sight in 19 countries since 1994
He returned to Italy to work at a hospital in Rho, to the northwest of Milan. A committed peace activist, he soon focussed his attention on trauma surgery and in particular the treatment of war victims.

In 1988, he began to work as a surgeon with the International Committee of the Red Cross in various conflict zones, including Pakistan, Ethiopia, Peru, Afghanistan, Thailand, Djibouti, Somalia and Bosnia.

He founded Emergency in 1994, along with his then-wife, Teresa, and with the support of colleagues. They provided their first medical services in Rwanda in the wake of the genocide there, when an 800,000 people were killed by Hutu extremists. 

Funded mainly through private donations, Emergency has cared for the civilian victims of land mines, improvised explosive devices, bombings, suicide attacks and of the diseases that flourish in communities without access to proper sanitation and medical services as a result of conflict.

Strada worked in Italy at the height of the Covid-19 pandemic
Strada worked in Italy at the
height of the Covid-19 pandemic
The organisation also cared for Ebola patients in Sierra Leone and, in Khartoum, Sudan, children whose hearts were damaged by rheumatic fever.

Emergency also set up a hospital in Afghanistan's Panjshir Valley, followed by others in Kabul and Lashkar Gah. Rigorously neutral in all conflicts, Strada spent several periods living in Afghanistan, where he once negotiated with Taliban leader Mohammed Omar and the leaders of rival Northern Alliance to ensure the safety of Emergency patients on both sides of the conflict. 

Strada preferred Emergency to remain non-political, but he found it impossible at times to be neutral. He opposed Italy’s involvement in Kosovo in 1999 and was an outspoken critic of the US-led invasion of Iraq in 2003. When Italy banned the manufacture, sale and export of anti-personnel landmines in 1997, it was in part due to a lobbying campaign by Emergency.

After decades taking on medical challenges in remote corners of the world, Strada found that the coronavirus pandemic created a demand for Emergency’s services in his native Italy, the first western country to be ravaged by the disease in 2020. The organisation provided medical care in the hardest-hit cities, as well as helping with delivering medicine and provisions for vulnerable people during lockdowns and handing out free food other essentials for Italians impacted by the economic consequences of the pandemic.

Widowed in 2009 when his wife, Teresa, died, Strada remarried in June 2021 to Simonetta Gola, Emergency's communications manager, but less than two months after the wedding he fell victim to a heart attack while on holiday in France and sadly passed away at the age of 73.

Although he had a history of heart trouble, his death came as a shock to many as he had shown no sign of slowing down.  His daughter by his first marriage, Cecilia, is a former president of Emergency. The current president is Rossella Miccio.

The suburb of Sesto San Giovanni in Milan
The suburb of Sesto San Giovanni in Milan has
transitioned from industrial to business centre
Travel tip:

Sesto San Giovanni, where Gino Strada was born, is the northernmost point on the Milan M1 metro line. In the 1920s it had a population of just over 15,000 but began to expand as an industrial centre, becoming the base for several large companies in the steel and motor industries but also the Campari drinks company.  The years after the Second World War saw a huge influx of migrants from other parts of Italy, attracted by the job possibilities. Today, the area is a busy suburb with more than 85,000 inhabitants. The current employers are more in the service sector, such as the telecommunications company, WIND.




The facade of Milano Centrale railway station
The facade of Milano Centrale railway station
was designed by Ulisse Stacchini in 1931
Travel tip:

Milano Centrale station, close to where Gino Strada went to high school, is one of Italy’s busiest rail hubs. It has 24 platforms and handles about 320,000 passengers per day, using approximately 500 trains. The station is an important stop on the north-south route between Bologna and Salerno and also has trains running daily to international destinations including Bern, Lugano, Geneva, Zürich, Paris, Vienna, Barcelona and Munich. It was designed by the architect Ulisse Stacchini, a champion of Liberty style Art Nouveau designs, who also designed the stadium that evolved into the city's iconic Stadio Giuseppe Meazza, joint home of Milan's two major football clubs, Internazionale and AC Milan.

Also on this day:

753 BC: The founding of the city of Rome

1574: The death of Tuscan leader Cosimo I de' Medici

1922: The death of castrato singer Alessandro Moreschi

1930: The birth of actress Silvana Mangano


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16 January 2022

Mario Tobino – poet, novelist and psychiatrist

Doctor was torn between literature and his patients

Tobino combined his work in mental health with a literary career
Tobino combined his work in mental
health with a literary career
The author and poet who was also a practising psychiatrist, Mario Tobino, was born on this day in 1910 in Viareggio in Tuscany.

Tobino was a prolific writer whose works dealt with social and psychological themes. His novel, Il clandestino, inspired by his experiences fighting as a partisan to liberate Italy in 1944, won him the Premio Strega, the most prestigious Italian literary award.

After completing his degree in medicine in 1936, Tobino embarked on a career working in a mental hospital, treating people with mental disabilities.

He went to work as a doctor in Libya in 1940 but had to flee when war broke out in the country. His experiences were recorded in his book, Il deserto della Libia, which was published in 1952.

In 1953, his novel, Libere donne di Magliano, established him as an important Italian writer. In 1972, another novel, Per le antiche scale won the Premio Campiello, an annual Italian literary award. Both novels were inspired by his experiences as a director of a psychiatric hospital at Maggiano, a suburb of Lucca.

His novel Il manicomio di Pechino, published in 1990, also drew on his medical experiences, his relationships with his patients and his personal dilemma as an individual divided by his allegiance to his profession and his passion for literature.

Per le antiche scale won
the Premio Campiello
Tobino’s strong attachment to his native region of Tuscany is another recurrent motif in his work. He published Gli ultimi giorni di Magliano followed by La ladra in 1984 and Tre amici in 1988. He received the Premio Pirandello on 10 December 1991 in Agrigento and died the next day, aged 81.

He began working in 1942 as a doctor at the mental hospital of Lucca on the outskirts of  the city at Maggiano, where he was to remain for the next 40 years. The hospital, known as Spedale per I Pazzi, was founded by the republic of Lucca in the second half of the 18th century and is thought to be the oldest mental hospital in Italy. It was also in 1942 that Tobino met Paola Olivetti, who was to be his life-long companion.

The Mario Tobino Foundation, based at the site of the former hospital in Via Fregionaia, which was closed in 1999, was created in 2006 to preserve and develop the important cultural heritage of his work as a writer and psychiatrist. The Foundation also aims to promote the regional and national debate about the future of psychiatric help.

Viareggio's sea front is famed for its Liberty-style architecture
Viareggio's sea front is famed for its
Liberty-style architecture
Travel tip:

Viareggio, where Mario Tobino was born, is a popular seaside resort in Tuscany with excellent sandy beaches and some beautiful examples of Liberty-style architecture. The remains of the English poet Shelley, who drowned at sea, were washed up on a beach near the resort in 1822. They were identified because of the volume of poetry by John Keats found in his pocket and he was cremated on the beach under the supervision of his friend, the poet Lord Byron. There is a monument to Shelley in Piazza Paolina in Viareggio.

The hospital complex retained some  features of the monastery
The hospital complex retained some 
features of the monastery
Travel tip:

The Spedale per I Pazzi, where Mario Tobino worked, was formed in 1773 at Maggiano after the Republic of Lucca had put forward a request to Pope Clement to suppress the Monastery of the Lateran Canons of Santa Maria of Fregionaia. The monastery was then adapted for the care of mental patients and was officially opened on 20 April 1773. The day after, the first 11 patients were transferred from Carcere Cittadino della Torre, the city’s Tower prison.



Also on this day:

1728: The birth of composer Niccolò Piccinni

1749: The birth of dramatist and poet Count Vittorio Alfieri

1941: The birth of controversial archbishop Carlo Maria Viganò

1957: The death of conductor Arturo Toscanini

1998: The death of interior and set designer Renzo Mongiardino


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24 September 2021

Girolamo Cardano - doctor and mathematician

Polymath was also a gambler and womaniser

Girolamo Cardano was the leading mathematician of Renaissance Italy
Girolamo Cardano was the leading
mathematician of Renaissance Italy
The Renaissance polymath Girolamo Cardano, whose range of talents included mathematics and medicine but who also invented a number of mechanical devices still in use today, was born on this day in 1501 in Pavia, then part of the Duchy of Milan.

Cardano, also known as Gerolamo, Hieronymus Cardanus in Latin and Jerome Cardan in English, is notable for writing Ars Magna which was the first Latin treatise devoted solely to algebra.

Far from being a stuffy academic, however, Cardano led a controversial life, practising as a physician without a licence and becoming proficient at gambling to keep himself solvent, while as a university professor being regularly accused of sexual impropriety with students.

In his wide range of interests, he seemed to be inspired by Leonardo da Vinci, who was a close friend of his father. Like Da Vinci, he wanted to put his mathematical and scientific skills to practical use and is credited with inventing among other things the first combination locks, the gimbal that allows a supported compass or gyroscope to rotate freely, and a universal joint that allows the transmission of rotation between the components of a drive train even when out of alignment.

A version of the joint in use today to connect the gearbox of a rear-wheel drive car with the rear axle is called a Cardan Shaft.

Girolamo Cardano was the illegitimate child of Fazio Cardano, a Milanese lawyer and university professor, and Chiara Micheria, a widow 20 years Fazio’s junior. Despite his mother’s attempts to abort the pregnancy, Girolamo was born at the home of some wealthy friends of his father in Pavia, where his mother was sent to escape an outbreak of plague in Milan that claimed the lives of her three other children.

The cover page of Ars Magna, seen as Cardano's magnum opus
The cover page of Ars Magna, seen
as Cardano's magnum opus
Girolamo survived a sickly childhood and, fascinated with philosophy and science, enrolled to read medicine at the University of Pavia, against the wishes of his father, who wanted him to study law.  The Italian War of 1521-26 forced the University of Pavia to close but he was able to resume his studies at the University of Padua.

There, however, he gained a reputation for being awkward and confrontational and while he obtained a doctorate he was denied admission to the College of Physicians in Milan, partly because he was not well liked and partly because of his illegitimacy.  

Unable to practise medicine legally in Milan, he moved to Saccolongo, a village outside Padua where he set up a practice despite his lack of a licence. He married Lucia, the daughter of a local militia captain, with whom he had three children.  His practice was not particularly successful, however, and he increasingly turned to gambling to make money, a habit he had developed while studying, but slipped further into debt.

Desperate for a change of fortune, he moved the family back to Milan. They had so little money they were forced to live in a poorhouse but Girolamo eventually elicited help from contacts of his father in the Milanese nobility, who arranged for him to be given his father’s former post of lecturer in mathematics at the Piatti Foundation in Milan.

For all that he was a difficult character, his brilliant mind was never in doubt and when the College of Physicians changed their attitude to illegitimacy he was granted his licence.  His success in treating his patients, some of whom had wide influence in Milan society, soon made him the most sought-after doctor in the city.

Cardano's universal joint is still used in the drive shafts of motor vehicles today
Cardano's universal joint is still used in the
drive shafts of motor vehicles today 
The next few years were his most productive. In 1537, he published the first of some 130 printed works, the most famous of which was Ars Magna, published in 1545. It included the first comprehensive solution for finding roots of cubic equations, which at the time was a subject that was the focus of much attention. Even that was the subject of controversy as Nicolo Tartaglia, another mathematician of note, accused Cardano of publishing results shared with him in confidence. 

He also wrote Liber de ludo aleae - Book on Games of Chance - which contains the first systematic treatment of probability, the basic concepts of which he had learned through his gambling. He also shared some of his secrets on how to cheat successfully.

Cardano did much of his inventing during this period, and enhanced his reputation as one of the world’s finest physicians, becoming rector of the College of Physicians that for so long rejected him. 

He turned down most invitations to work outside Italy but made an exception when asked to travel to Scoland, where John Hamilton, Archbishop of St Andrews, was suffering increasingly severe asthma attacks that the physicians of both the French king and German emperor had been unable to keep in check.

Cardano was also known for his chaotic and controversial personal life
Cardano was also known for his chaotic
and controversial personal life
Cardano was welcomed as a celebrity when he landed in Scotland, where he was promised a substantial payment if he could treat the Archbishop successfully. In the event, he quickly established that feather pillows were the cause of the Archbishop’s malady and the patient made a full recovery.

For all that he was ultimately hailed as a genius, Cardano's personal life was filled with tragedy.

Lucia died in 1546, his eldest son was executed for poisoning his wife and his daughter died of syphilis. He disowned his second son, who stole money from him to fund his own gambling addiction.

Cardano was appointed a professor of medicine at the University of Bologna but as the father of a convicted murderer he was shunned by many colleagues, while his arrogant manner made him many enemies.  A shameless womaniser, he was frequently accused of using his power to coerce female students into inappropriate relationships.

In 1570 he spent a short time in jail, having been accused of heresy after publishing a horoscope of Jesus Christ.  It cost him his position at the University of Bologna.

Nonetheless, on moving to Rome he received a lifetime annuity from Pope Gregory XIII and was accepted in the Royal College of Physicians. He continued to practise medicine and expanded his philosophical studies. 

He died in Rome in 1576 at the age of 74. 

The covered bridge linking Pavia with the area known as Borgo Ticino
The covered bridge linking Pavia with the
area known as Borgo Ticino
Travel tip:

Pavia is a city in Lombardy, about 46km (30 miles) south of Milan. Its university was founded in 1361 and was the sole university in the Duchy of Milan until the 19th century. As well as Girolamo Cardano, its alumni include explorer Christopher Columbus, physicist Alessandro Volta and the poet and revolutionary Ugo Foscolo. Pavia is also famous for its Certosa, a magnificent Renaissance monastery complex north of the city that dates back to 1396 and includes a number of important sculptures and frescoes. A pretty covered bridge over the River Ticino leads to Borgo Ticino, where the inhabitants claim to be the true people of Pavia.

Giotto's frescoes cover the inner walls of the Scrovegni Chapel
Giotto's frescoes cover the inner
walls of the Scrovegni Chapel
Travel tip:

Padua in the Veneto is one of the most important centres for art in Italy and home to the country’s second oldest university. Padua has become acknowledged as the birthplace of modern art because of the Scrovegni Chapel, the inside of which is covered with frescoes by Giotto, an artistic genius who was the first to paint people with realistic facial expressions showing emotion. His scenes depicting the lives of Mary and Joseph, painted between 1303 and 1305, are considered his greatest achievement and one of the world’s most important works of art. At Palazzo Bo, where Padua’s university was founded in 1222, you can still see the original lectern used by Galileo and the world’s first anatomy theatre, where dissections were secretly carried out from 1594.

Also on this day:

1934: The birth of exiled Princess Maria Pia of Bourbon-Parma

1954: The birth of footballer Marco Tardelli

1955: The birth of businessman Riccardo Illy


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12 October 2019

Ascanio Sobrero - chemist

Professor who discovered nitroglycerine


Ascanio Sobrero discovered nitroglycerine during an experiment in his laboratory at Turin University
Ascanio Sobrero discovered nitroglycerine during
an experiment in his laboratory at Turin University
The chemist Ascanio Sobrero, who discovered of the volatile compound that became known as nitroglycerine, was born on this day in 1812 in Casale Monferrato in Piedmont.

Nitroglycerine has a pharmaceutical use as a vasodilator, improving blood flow in the treatment of angina, but it is more widely known as the key ingredient in explosives such as dynamite and gelignite.

Its commercial potential was exploited not by Sobrero but by Alfred Nobel, the Swedish businessman and philanthropist who gave his name to the annually awarded Nobel Prizes.

Sobrero, aware of how much damage it could cause, had actually warned against nitroglycerine being used outside the laboratory.

Little is known about Sobrero’s early life, apart from his being born in Casale Monferrato, a town about 60km (37 miles) east of Turin.

He studied medicine in Turin and Paris and then chemistry at the University of Giessen in Germany, earning his doctorate in 1832. In 1845 he returned to the University of Turin, becoming a professor there.

Alfred Nobel, pictured at around the time he met Sobrero in Paris in 1850
Alfred Nobel, pictured at around the time he met
Sobrero in Paris in 1850
Sobrero had acquired some knowledge of explosives from the French chemist Théophile-Jules Pelouze, who had taught at the University of Turin while he was a student.

Around 1846 or 1847, during research, Sobrero experimented by adding glycerol to a mixture of concentrated nitric and sulfuric acids. The result was a colorless, oily liquid with a sweet, burning taste.

When he tried heating a drop in a test tube, it exploded. The fragments of glass scarred Sobrero’s face and hands. The liquid’s volatility frightened Sobrero so much that he told no one about it for more than a year. After he did finally announce his discovery, which he called pyroglycerine, he wrote to fellow chemists warning against its use, expanding on his misgivings in academic journals.

Nobel, whose family owned an armaments business in St Petersburg, had been, like Sobrero, a student at the University of Turin, albeit somewhat later.  They happened to meet in Paris in 1850.  On learning about Sobrero’s discovery, Nobel became interested in finding a way to control nitroglycerine’s explosive qualities.

It took him many years to achieve that ambition and there were mishaps along the way, not least in 1864, after the family had returned to Sweden from Russia, when an explosion at their factory in Heleneborg, Stockholm, killed five people, including Nobel's younger brother Emil. Undaunted, Nobel continued his work and in 1867 he obtained a patent as the inventor of dynamite. He went on to invent gelignite and ballistite, a predecessor of cordite.

The Nobel family business was still producing dynamite to Alfred's patented formula in the 1930s
The Nobel family business was still producing dynamite
to Alfred's patented formula in the 1930s
The inventions made Nobel’s fortune. He unfailingly acknowledged Sobrero as the man who had discovered nitroglycerine, although Sobrero sometimes claimed he was not given sufficient recognition.

At other times, by contrast, he gave the impression he would rather Nobel did not mention his name at all.  He was on record as saying: “When I think of all the victims killed during nitroglycerine explosions, and the terrible havoc that has been wreaked, which in all probability will continue to occur in the future, I am almost ashamed to admit to be its discoverer.”

Sobrero died in Turin in 1888, at the age of 75.  He is buried at the cemetery of Cavallermaggiore, about 40km (25 miles) south of Turin.

Piazza Mazzini in Casale Monferrato, which is named after the revolutionary hero Giuseppe Mazzini
Piazza Mazzini in Casale Monferrato, which is named
after the revolutionary hero Giuseppe Mazzini
Travel tip:

Situated on the south bank of the Po river, Casale Monferrato is a town of some 36,000 inhabitants based on a former Roman city, later turned into a major citadel by the Gonzaga family. The historic centre is itself centred on Piazza Mazzini, the site of the Roman forum. The square is dominated by an 1843 equestrian statue by Abbondio Sangiorgio of King Charles Albert of Piedmont-Sardinia.  To the east of the square is the Lombard Romanesque cathedral of Sant'Evasio, founded in 742 and rebuilt in the early 12th century, occupying the site of a Roman temple dedicated to Jupiter.  See also the castle on Piazza Castello, a fortress that probably dates from 1000, built to a quadrilateral plan with corner towers and a moat.

An internal quadrangle at the University of Turin, where Sobrero was a student and later a professor
An internal quadrangle at the University of Turin, where
Sobrero was a student and later a professor
Travel tip:

The University of Turin, where Sobrero studied and taught, is one of the oldest universities in Europe, founded in 1406 by Prince Ludovico di Savoia. It consistently ranks among the top five universities in Italy and is an important centre for research. The university departments are spread around 13 facilities, with the main university buildings in Via Giuseppe Verdi, close to Turin’s famous Mole Antonelliana.

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4 October 2019

Bernardino Ramazzini - physician

Pioneer in knowledge of occupational diseases, cancer and malaria


Ramazzini worked in medicine for more than half a century
Ramazzini worked in medicine
for more than half a century
The physician Bernardino Ramazzini, often described as the “father of occupational medicine” and responsible also for pioneering work in the study of cancer and the treatment of malaria, was born in Carpi in Emilia-Romagna on this day in 1633.

Ramazzini’s tour de force, which he completed at the age of 67, was his book De Morbis Artificum Diatriba - Discourse of the Diseases of Workers - which came to be regarded as a seminal work in his field, the lessons from which still influence practice today in the prevention and treatment of occupational diseases.

A student at the University of Parma, Ramazzini was appointed chair of theory of medicine at the University of Modena in 1682 and professor of medicine at the University of Padua from 1700 until his death in 1714.

It was while he was in Parma that he began to take an interest in diseases suffered by workers.

When he became a departmental head at Modena, he began to study the health problems of workers in a more systematic way.  He would visit their workplaces, observe the activities they undertook in their work and discuss their health problems with them.

Ramazzini could see that some diseases were attributable to the materials they worked with, including chemicals that would now be classified as hazardous, or the dangers posed by equipment.

The first page of the 1713 edition of Ramazzini's work on the study of occupational diseases
The first page of the 1713 edition of Ramazzini's work
on the study of occupational diseases
Where he was ahead of his time was in observation that other ailments common among workers appeared to be related to how they carried out their work, and whether it involved prolonged, violent, and irregular movements.

Ramazzini saw a relationship between certain disorders and the repetition of particular motions, or the lifting of heavy objects, but also noted that certain diseases appeared to be prevalent in workers whose environment restricted the amount of movement, such as sitting for long periods.

This research formed the basis of many of his lectures and he recommended to doctors treating sick patients that their diagnostic questions should include asking about the patient’s place of work.

Ultimately Ramazzini was able to group his findings in to four areas: occupations that require workers to handle minerals and metals or other raw materials extracted from the earth; workers exposed to air-borne toxins; workers exposed to fluids such as water, milk and alcoholic beverages; and workers whose jobs involved unnatural postures or positions held for long periods.

Ramazzini made important observations about cancer and malaria
Ramazzini made important observations
about cancer and malaria
He also emphasised, again displaying a level of understanding that was perhaps centuries ahead of his time, that other factors could be linked to the degree to which an individual’s working environment impacted his or her health, such as social status and lifestyle.

Ramazzini took 10 years to bring together all his observations in De Morbis Artificum Diatriba, which carried the authority of more than 40 years in medical practice.  He urged physicians to promote the thinking that prevention was as important in cure.

Away from occupational health, Ramazzini was one of the first to point science towards the role that hormones might play in the development of some cancers.  This was based on his observations that there was a virtual absence of cervical cancer among nuns, but a high incidence of breast cancer, which he postulated as possibly due to their abstinence from sexual activity.

He was also one of the first to support the use of quinine - found in the bark of the cinchona tree - as a treatment for malaria.

Ramazzini died in Padua in November, 1714.

The Castello del Pio on Piazza Martiri in Carpi, one of the largest public squares in Italy
The Castello del Pio on Piazza Martiri in Carpi, one of the
largest public squares in Italy
Travel tip:

Carpi, where Ramazzini was born, is situated about 18km (11 miles) north of Modena in the Padana plain. It became a wealthy town during the era of industrial development in Italy as a centre for textiles and mechanical engineering. Its historic centre, which features a town hall housed in a former castle, is based around the Renaissance square, the Piazza Martiri, the third largest square in Italy. Italy’s national marathon has finished in Carpi in 1988 in honour of another of the town’s famous sons, the marathon runner Dorando Pietri.

The Duomo and Palazzo Communale in Piazza Grande in the heart of Modena
The Duomo and Palazzo Communale in Piazza Grande
in the heart of Modena
Travel tip:

Modena, where Ramazzini spent part of his academic life, is a city on the south side of the Po Valley.  It is known for its car industry, as Ferrari, De Tomaso, Lamborghini, Pagani and Maserati have all been located there. The city is also well known for producing balsamic vinegar. Operatic tenor Luciano Pavarotti and soprano Mirella Freni were both born in Modena.  One of the main sights in Modena is the huge, baroque Ducal Palace, which was begun by Francesco I on the site of a former castle in 1635. His architect, Luigi Bartolomeo Avanzini, created a home for him that few European princes could match at the time. The palace is now home to the Italian national military academy.

Also on this day:

1657: The birth of Neapolitan painter Francesco Solimena

1720: The birth of print maker and architect Giovanni Battista Piranesi

The Feast of Saint Francis of Assisi


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11 March 2019

Franco Basaglia - psychiatrist

Work led to closure of mental hospitals by law


Franco Basaglia was destined for an academic career until the University of Padua deemed him too unconventional
Franco Basaglia was destined for an academic career until
the University of Padua deemed him too unconventional
The psychiatrist Franco Basaglia, whose work ultimately led to changes in the law that resulted in the closure and dismantling of Italy’s notorious psychiatric hospitals, was born on this day in 1924 in Venice.

As the founder of the Democratic Psychiatry movement and the main proponent of Law 180 - Italy's Mental Health Act of 1978 - which abolished mental hospitals, he is considered to be the most influential Italian psychiatrist of the 20th century.

His Law 180 - also known as Basaglia’s Law - had worldwide impact as other countries took up the Italian model and reformed their own way of dealing with the mentally ill.

Basaglia was born to a well-off family in the San Polo sestiere of Venice. He became an anti-Fascist in his teens and during the Second World War was an active member of the resistance in the city, to the extent that in December 1944, he was arrested and spent six months inside Venice’s grim Santa Maria Maggiore prison, being released only when the city was liberated in April of the following year.

He graduated in medicine and surgery from the University of Padua in 1949 and seemed destined for an academic career but after qualifying as a doctor in the field of ‘nervous and mental diseases’ and becoming an assistant professor he was deemed too unconventional for the tastes of the university hierarchy and told he should seek a career elsewhere.

Basaglia believed mental hospitals merely  reinforced the health problems of patients
Basaglia believed mental hospitals merely
reinforced the health problems of patients
As a result, Basaglia had to look for work and when he was appointed director of the provincial asylum in Gorizia, close to the border with Yugoslavia in northeastern Italy.

It was a grim job. Gorizia, 140km (87 miles) from Venice, was like a remote outpost and psychiatrists at the time regarded it as a sign of failure if they were forced to work in asylums. But Basaglia felt he had no choice.

In his studies he had already become convinced that the conventional methods for handling psychiatric patients needed to change and the post at Gorizia offered him the chance to put his ideas into practice.

On his first day in charge, he refused to sign the permits for the restraint of prisoners. He had soon introduced a requirement that doctors did not wear white coats and instead mingled freely with patients. Locked wards were opened, and the use of shackles and straitjackets was quickly outlawed.

He felt the traditional institutional response to psychiatric patients in distress, which revolved around physical abuse, forced restraint and appalling ‘punishments’, did nothing except reinforce the presumed ‘insanity’ of the victims.

Although he faced opposition from the older staff, he gradually replaced them with doctors he felt shared his views. Amid the tide of radical thinking that was sweeping Italy in the late 1960s, he published a book, L’istituzione negata - The Institution Denied - describing the methods being employed at Gorizia. It became a bestseller and a TV documentary based on the book made him famous.

Basaglia believed strongly in the rehabilitation of the victims of mental illness sufferers in the community
Basaglia believed strongly in the rehabilitation of the
victims of mental illness sufferers in the community
Occasionally, his determination to rehabilitate patients had tragic consequences. On at least two occasions, individuals he had allowed out of confinement committed murders. Basaglia was tried for manslaughter in both instances, and both times was cleared of the charge.

Basaglia left Gorizia in 1969, after which he a brief period in charge of the asylum in Colorno, near Parma, and six months in New York where he worked in a psychiatric hospital in Brooklyn. In 1971, he returned to Italy to be director of the San Giovanni psychiatric hospital in Trieste.

By then, other psychiatrists in Italy were putting Basaglia’s methods into practice and his ideas were acquiring political support. He repeated at the Trieste institution many of the measures that had proved successful in Gorizia, with the addition of such steps as launching co-operatives so that patients who were considered well enough could be re-integrated into the world of work. In 1977 he announced that the San Giovanni hospital was to close.

Soon afterwards, politicians successfully argued that a programme of closure should begin at psychiatric hospitals across the country.

Franca Ongaro continued Basaglia's work after his death
Franca Ongaro continued Basaglia's
work after his death
The Italian Parliament approved Law 180 on May 13, 1978, initiating the gradual dismantling of psychiatric hospitals, a process completed over the following 20 years.

In their place was to be a decentralised community service of treating and rehabilitating mental patients and preventing mental illness and promoting comprehensive treatment, particularly through services outside a hospital network. The emphasis in mental health moved from protecting society towards meeting the needs of patients.

Basaglia was described as a charismatic figure, so enthused about his work he would stay up all night talking with anyone who could match his intellectual stamina. He was also a heavy smoker. Sadly, by the time Basaglia’s Law came into force, he was suffering the effects of the brain tumour that would kill him.

He returned to San Polo, where he died in 1980 at the age of only 56. His wife, Franca Ongaro, who had worked with him on many of his books and essays, continued to work on his behalf after his death to ensure Basaglia’s Law was fully implemented.

The Basilica Maria Gloriosa dei Frari is one of the most notable churches in the San Polo sestiere of Venice
The Basilica Maria Gloriosa dei Frari is one of the
most notable churches in the San Polo sestiere of Venice
Travel tip:

San Polo, the smallest of the six Venice sestieri, is a vibrant district on the west side of the Grand Canal connected to the eastern side by the Rialto Bridge. The main sights include the Rialto Market, the 15th century Gothic church of San Polo and the imposing Basilica di Santa Maria Gloriosa dei Frari, usually just called the Frari, built in brick in the Venetian Gothic style and containing monuments to distinguished Venetians buried in the church, including a number of Doges and the painter Titian, who painted two large and important altarpieces that can be seen inside, the Assumption of the Virgin on the high altar and the Pesaro Madonna. where stalls sell fish, fruit and vegetables. The canalside Erbaria area has become a fashionable meeting place for aperitifs and cicchetti - the small snacks that are a kind of Venetian tapas.




The Piazza della Vittoria is the central square in the town of Gorizia, on the Italian border with Slovenia
The Piazza della Vittoria is the central square in the
town of Gorizia, on the Italian border with Slovenia
Travel tip:

Gorizia has the look of an historic Italian town but it has changed hands several times during its history, which is not surprising given its geographical location.  It sits literally on the border with Slovenia and, in fact, is part of a metropolitan area shared by the two countries, the section on the Slovenian side being now known as Nova Gorica. It has German, Slovenian, Friulian and Venetian influences, which can be experienced in particular in the local cuisine.

22 February 2019

Renato Dulbecco - Nobel Prize-winning physiologist

Research led to major breakthrough in knowledge of cancer


Renato Dulbecco emigrated to the United States 1946 after studying at the University of Turin
Renato Dulbecco emigrated to the United States
1946 after studying at the University of Turin
Renato Dulbecco, a physiologist who shared the 1975 Nobel Prize in Physiology or Medicine for his role in drawing a link between genetic mutations and cancer, was born on this day in 1914 in Catanzaro in Calabria.

Through a series of experiments that began in the late 1950s after he had emigrated to the United States, Dulbecco and two colleagues showed that certain viruses could insert their own genes into infected cells and trigger uncontrolled cell growth, a hallmark of cancer.

Their findings transformed the course of cancer research, laying the groundwork for the linking of several viruses to human cancers, including the human papilloma virus, which is responsible for most cervical cancers.

The discovery also provided the first tangible evidence that cancer was caused by genetic mutations, a breakthrough that changed the way scientists thought about cancer and the effects of carcinogens such as tobacco smoke.

Dulbecco, who shared the Nobel Prize with California Institute of Technology (Caltech) colleagues Howard Temin and David Baltimore, then examined how viruses use DNA to store their genetic information and, in his studies of breast cancer, pioneered a technique for identifying cancer cells by the proteins present on their surface.

Dulbecco found that viruses such as the human papilloma virus could cause cell mutations
Dulbecco found that viruses such as the human
papilloma virus could cause cell mutations
His proposal in 1986 to catalogue all human genes can be seen as the beginnings of the Human Genome Project, which was completed in 2003.

The son of a civil engineer, Dulbecco grew up in Liguria after his family moved from Catanzaro to the coastal city of Imperia. He graduated from high school at 16 and went on to the University of Turin, receiving his medical degree in 1936. He became friends there with two other future Nobel prizewinners, Rita Levi-Montalcini and Salvador Luria, who were fellow students.

Immediately upon graduating, he was required to do two years’ military service. He was discharged in 1938 but soon afterwards called up again as Italy entered the Second World War, joining the Italian Army as a medical officer.

His role eventually took him to the Russian front, where he suffered an injury to his shoulder that meant he was sent back to Italy to recuperate. Disillusioned with Mussolini and horrified at learning of the fate of Jews under Hitler, he decided not to return to the Army, joining the resistance instead. He stationed himself in a remote village outside Turin, tending to injured partisans.

After the war, he was briefly involved with politics, firstly on the Committee for National Liberation in Turin and then on the city council, but soon returned to Turin University to study physics and conduct biological research.

Dulbecco's fellow Turin University graduate Salvador Duria also moved to America
Dulbecco's fellow Turin University graduate
Salvador Duria also moved to America
With the encouragement of Levi-Montalcini, who would win a Nobel Prize in 1986 for her work in neurobiology, in 1946, he moved to United States, rejoining Luria, who shared a Nobel in 1969 for discoveries about the genetics of bacteria, at Indiana University, where they studied viruses. In the summer of 1949 he moved to Caltech, where he began his work on animal oncoviruses.

Dulbecco worked with Dr. Marguerite Vogt on a method of determining the amount of polio virus present in cell culture, a step that was vital in the development of polio vaccine, before becoming intrigued by a thesis written by Howard Temin on the connection between viruses and cancer.

He left Caltech in 1962 to move to the Salk Institute, a polio research facility in San Diego, and then in 1972 to the Imperial Cancer Research Fund (now Cancer Research UK) in London.

There was a mixed reaction in Italy when it was learned that ‘their’ Nobel Prize winner had become an American citizen. In fact, his Italian citizenship was revoked, although when he moved back to Italy in 1993 to spend four years as president of the Institute of Biomedical Technologies at National Council of Research in Milan he was made an honorary citizen.

Married twice, with three children, Dulbecco died in La Jolla, California, in 2012, three days before what would have been his 98th birthday.

From its elevated position, Catanzaro has views towards the Ionian Sea and the resort of Catanzaro Lido
From its elevated position, Catanzaro has views towards
the Ionian Sea and the resort of Catanzaro Lido
Travel tip:

Occupying a position 300m (980ft) above the Gulf of Squillace, Catanzaro is known as the City of the Two Seas because, from some vantage points, it is possible to see the Tyrrhenian Sea to the north of the long peninsula occupied by Calabria as well as the Ionian Sea to the south.  The historic centre, which sits at the highest point of the city, includes a 16th century cathedral built on the site of a 12th century Norman cathedral which, despite being virtually destroyed by bombing in 1943, has been impressively restored.  The city is about 15km (9 miles) from Catanzaro Lido, which has a long white beach typical of the Gulf of Squillace.




The waterfront of the Ligurian port city of Imperia, with the Basilica of San Maurizio on top of the hill
The waterfront of the Ligurian port city of Imperia, with
the Basilica of San Maurizio on top of the hill
Travel tip:

The beautiful city of Imperia, on Liguria's Riviera Poniente about 120km (75 miles) west of Genoa and 60km (37 miles) from the border with France, came into being in 1923 when the neighbouring ports of Porto Maurizio and Oneglia, either side of the Impero river, were merged along with several surrounding villages to form one conurbation.  Oneglia, once the property of the Doria family in the 13th century, has become well known for cultivating flowers and olives. Porto Maurizio, originally a Roman settlement called Portus Maurici, has a classical cathedral dedicated to San Maurizio, which was built by Gaetano Cantoni and completed in the early 19th century.