Umberto Veronesi - oncologist

Pioneered new techniques for treating breast cancer

Umberto Veronesi made an important
contribution to breast cancer treatment 

Umberto Veronesi, an oncologist whose work in finding new methods to treat breast cancer spared many women faced with a full mastectomy, was born on this day in 1925 in Milan.

Along with many other contributions to the knowledge of breast cancer and breast cancer prevention over a 50-year career, Veronese was a pioneer of breast-conserving surgery in early breast cancer as an alternative to a radical mastectomy. 

He developed the technique of quadrantectomy, which limits surgical resection to the affected quarter of the breast. 

This more limited resection became standard practice for the treatment of breast cancer detected early after Veronesi led the first prospective randomised trial of breast-conserving surgery, which compared outcomes from radical mastectomy against his quadrantectomy over a 20-year period.

Veronesi supported and promoted research aimed at improving conservative surgical techniques in general and conducting studies on tamoxifen and retinoids which helped verify their effectiveness in preventing the formation of cancer in the first place. 

The founder and president of the Umberto Veronesi Foundation, he founded and held the role of scientific director and scientific director emeritus of the European Institute of Oncology, was scientific director of the National Cancer Institute of Milan and held the position of Minister of Health from April 2000 to June 2001 in the second government of prime minister Giuliano Amati.

Veronesi grew up in Casoretto, which was then an agricultural suburb of Milan, where his father was a tenant farmer.  He was one of six children. The family home was relatively remote, the only source of heat in the winter a fireplace in the kitchen. Going to school necessitated a 5km (three miles) walk to school and back, but his parents were determined that their five sons and a daughter would enjoy a good education.

Veronesi pictured at a book signing in 2013, still
working at the age of 87

Veronesi’s father died when he was still a child but the memory of beatings handed out by Fascist squadristi meant that his father’s left-wing politics had a more profound effect on him than his mother’s devout Catholicism. He declared himself to be an agnostic at the age of 14.

He began to focus on cancer soon after graduating in medicine and surgery at the University of Milan in 1951 and specialising in surgery at the University of Pavia. He travelled to England and France to broaden his knowledge and joined the National Cancer Institute, of which he would become director-general in 1975, as a volunteer.

In the course of what would be a brilliant career, his far-sighted ideas were not well received initially and he had to fight to convince others.  Yet in time his scientific projects opened new boundaries in cancer treatment.  His belief in joining forces with patients, communicating with them clearly about their treatment and enlisting their help in campaigns to raise funds helped change attitudes towards the disease.

Veronesi too was instrumental in removing regulatory barriers in the management of terminal cancer patients, making opioid painkillers available to those whose cancer could not be cured.

Veronesi (right) with then president
Giorgio Napolitano in 2011

Away from the main focus of his life, Veronesi became politically active when the left-wing politician Bettino Craxi invited him to become a member of the national assembly of the Italian Socialist Party (PSI).  In April 2000 he was Minister of Health in the second Amato government, using his platform to campaign for an anti-smoking law.  He was later elected to the Senate as a member of the Democratic Party.

President of the Italian Nuclear Safety Agency from 2010-11, he resigned from that position in protest at the Berlusconi government for failing to provide the agency with even the minimum structures to carry out its activities.

He was a strong advocate of animal rights, believed in voluntary euthanasia and, controversially, supported the genetic modification of food because of its possibilities for helping parts of the world prone to crop failures and famine, and for removing naturally occurring carcinogens. 

His outspoken opposition to doctors’ strikes in the 1980s, however, caused him to fall foul of the Red Brigades, whose death threats left him looking over his shoulder in public for several years.

Veronesi died at home in November 2016 not long before what would have been his 91st birthday. After a secular funeral at Palazzo Marino, Milan’s city hall, where his son, Alberto, a conductor, led two musical pieces by Beethoven and Puccini, his body was cremated. 

Via Casoretto, looking towards the church of
Santa Maria Bianca della Misericordia

Travel tip:

The Casoretto of today is a neighbourhood in the northeastern suburbs of Milan, forming part of an area locally known as NoLo, an acronym for North of Loreto. The area is multicultural with a vibrant nightlife, art galleries and restaurants. Casoretto is notable for colourful houses and an unusually high number of cycle repair shops, reflecting local beliefs in eco-friendly travel.  The neighbourhood fans out from the central Via Casoretto and the church of Santa Maria Bianca della Misericordia, which is sometimes known as the Abbey of Casoretto. Until the start of the 20th century and industrialisation, the area was characterised by farmhouses and cultivated fields, with no significant residential areas apart from a few farmhouses and other buildings around the Abbey.

Palazzo Marino, with the entrace to the Galleria
Vittorio Emanuele II to the right of the picture

Travel tip:

Palazzo Marino, where Veronesi’s secular funeral was held, is a 16th-century palace located in Piazza della Scala, in the centre of Milan. Standing opposite the world-famous opera house, Teatro alla Scala, and next to the northern entrance to the Galleria Vittorio Emanuele II, it has been Milan’s city hall since 1861. Designed by architect Galeazzo Alessi, it was built between 1557 and 1563 for Tommaso Marino, a wealthy Genovese banker and merchant.  After Marino died, leaving his family bankrupt, the palace became the property of the state before being sold to another banker, Carlo Omodei, who did not live there himself but rented it out to other notable Milanese, before reverting to state ownership in 1781. After being established as the seat of Milan’s municipal government in 1861, the palace was given a new facade to coincide with the creation of Piazza della Scala, undergoing a second major restoration after it was badly damaged by bombing in World War Two. 

Also on this day:

1873: The death of astronomer Caterina Scarpellini

1907: The birth of novelist Alberto Moravia

1913: The birth of composer Mario Nascembene

1941: The birth of actress Laura Antonelli

1955: The birth of footballer Alessandro Altobelli

1977: The birth of World Cup hero Fabio Grosso

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Renato Dulbecco - Nobel Prize-winning physiologist

Research led to major breakthrough in knowledge of cancer

Renato Dulbecco emigrated to the United States
1946 after studying at the University of Turin

Renato Dulbecco, a physiologist who shared the 1975 Nobel Prize in Physiology or Medicine for his role in drawing a link between genetic mutations and cancer, was born on this day in 1914 in Catanzaro in Calabria.

Through a series of experiments that began in the late 1950s after he had emigrated to the United States, Dulbecco and two colleagues showed that certain viruses could insert their own genes into infected cells and trigger uncontrolled cell growth, a hallmark of cancer.

Their findings transformed the course of cancer research, laying the groundwork for the linking of several viruses to human cancers, including the human papilloma virus, which is responsible for most cervical cancers.

The discovery also provided the first tangible evidence that cancer was caused by genetic mutations, a breakthrough that changed the way scientists thought about cancer and the effects of carcinogens such as tobacco smoke.

Dulbecco, who shared the Nobel Prize with California Institute of Technology (Caltech) colleagues Howard Temin and David Baltimore, then examined how viruses use DNA to store their genetic information and, in his studies of breast cancer, pioneered a technique for identifying cancer cells by the proteins present on their surface.

Dulbecco found that viruses such as the human
papilloma virus could cause cell mutations

His proposal in 1986 to catalogue all human genes can be seen as the beginnings of the Human Genome Project, which was completed in 2003.

The son of a civil engineer, Dulbecco grew up in Liguria after his family moved from Catanzaro to the coastal city of Imperia. He graduated from high school at 16 and went on to the University of Turin, receiving his medical degree in 1936. He became friends there with two other future Nobel prizewinners, Rita Levi-Montalcini and Salvador Luria, who were fellow students.

Immediately upon graduating, he was required to do two years’ military service. He was discharged in 1938 but soon afterwards called up again as Italy entered the Second World War, joining the Italian Army as a medical officer.

His role eventually took him to the Russian front, where he suffered an injury to his shoulder that meant he was sent back to Italy to recuperate. Disillusioned with Mussolini and horrified at learning of the fate of Jews under Hitler, he decided not to return to the Army, joining the resistance instead. He stationed himself in a remote village outside Turin, tending to injured partisans.

After the war, he was briefly involved with politics, firstly on the Committee for National Liberation in Turin and then on the city council, but soon returned to Turin University to study physics and conduct biological research.

Dulbecco's fellow Turin University graduate
Salvador Duria also moved to America

With the encouragement of Levi-Montalcini, who would win a Nobel Prize in 1986 for her work in neurobiology, in 1946, he moved to United States, rejoining Luria, who shared a Nobel in 1969 for discoveries about the genetics of bacteria, at Indiana University, where they studied viruses. In the summer of 1949 he moved to Caltech, where he began his work on animal oncoviruses.

Dulbecco worked with Dr. Marguerite Vogt on a method of determining the amount of polio virus present in cell culture, a step that was vital in the development of polio vaccine, before becoming intrigued by a thesis written by Howard Temin on the connection between viruses and cancer.

He left Caltech in 1962 to move to the Salk Institute, a polio research facility in San Diego, and then in 1972 to the Imperial Cancer Research Fund (now Cancer Research UK) in London.

There was a mixed reaction in Italy when it was learned that ‘their’ Nobel Prize winner had become an American citizen. In fact, his Italian citizenship was revoked, although when he moved back to Italy in 1993 to spend four years as president of the Institute of Biomedical Technologies at National Council of Research in Milan he was made an honorary citizen.

Married twice, with three children, Dulbecco died in La Jolla, California, in 2012, three days before what would have been his 98th birthday.

From its elevated position, Catanzaro has views towards
the Ionian Sea and the resort of Catanzaro Lido

Travel tip:

Occupying a position 300m (980ft) above the Gulf of Squillace, Catanzaro is known as the City of the Two Seas because, from some vantage points, it is possible to see the Tyrrhenian Sea to the north of the long peninsula occupied by Calabria as well as the Ionian Sea to the south.  The historic centre, which sits at the highest point of the city, includes a 16th century cathedral built on the site of a 12th century Norman cathedral which, despite being virtually destroyed by bombing in 1943, has been impressively restored.  The city is about 15km (9 miles) from Catanzaro Lido, which has a long white beach typical of the Gulf of Squillace.

Hotels in Catanzaro by Booking.com

The waterfront of the Ligurian port city of Imperia, with
the Basilica of San Maurizio on top of the hill

Travel tip:

The beautiful city of Imperia, on Liguria's Riviera Poniente about 120km (75 miles) west of Genoa and 60km (37 miles) from the border with France, came into being in 1923 when the neighbouring ports of Porto Maurizio and Oneglia, either side of the Impero river, were merged along with several surrounding villages to form one conurbation.  Oneglia, once the property of the Doria family in the 13th century, has become well known for cultivating flowers and olives. Porto Maurizio, originally a Roman settlement called Portus Maurici, has a classical cathedral dedicated to San Maurizio, which was built by Gaetano Cantoni and completed in the early 19th century.

Stay in Imperia with Booking.com


More reading:

How Salvador Luria reached the United States after fleeing Paris on a bicycle

Grazia Deledda - the first Italian woman to win a Nobel Prize

The first physiologist to explain human movement

Also on this day:

1876: The birth of opera singer and director Giovanni Zenatello

1905: The birth of industrialist Enrico Piaggio

1921: The birth of actress Giulietta Masina

1990: The death of Autogrill pioneer Mario Pavesi

(Picture credits: Catanzaro view by Salvatore Migliari; Imperia waterfront by BMK)

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