Renato Dulbecco - Nobel Prize-winning physiologist

Research led to major breakthrough in knowledge of cancer

Renato Dulbecco emigrated to the United States
1946 after studying at the University of Turin

Renato Dulbecco, a physiologist who shared the 1975 Nobel Prize in Physiology or Medicine for his role in drawing a link between genetic mutations and cancer, was born on this day in 1914 in Catanzaro in Calabria.

Through a series of experiments that began in the late 1950s after he had emigrated to the United States, Dulbecco and two colleagues showed that certain viruses could insert their own genes into infected cells and trigger uncontrolled cell growth, a hallmark of cancer.

Their findings transformed the course of cancer research, laying the groundwork for the linking of several viruses to human cancers, including the human papilloma virus, which is responsible for most cervical cancers.

The discovery also provided the first tangible evidence that cancer was caused by genetic mutations, a breakthrough that changed the way scientists thought about cancer and the effects of carcinogens such as tobacco smoke.

Dulbecco, who shared the Nobel Prize with California Institute of Technology (Caltech) colleagues Howard Temin and David Baltimore, then examined how viruses use DNA to store their genetic information and, in his studies of breast cancer, pioneered a technique for identifying cancer cells by the proteins present on their surface.

Dulbecco found that viruses such as the human
papilloma virus could cause cell mutations

His proposal in 1986 to catalogue all human genes can be seen as the beginnings of the Human Genome Project, which was completed in 2003.

The son of a civil engineer, Dulbecco grew up in Liguria after his family moved from Catanzaro to the coastal city of Imperia. He graduated from high school at 16 and went on to the University of Turin, receiving his medical degree in 1936. He became friends there with two other future Nobel prizewinners, Rita Levi-Montalcini and Salvador Luria, who were fellow students.

Immediately upon graduating, he was required to do two years’ military service. He was discharged in 1938 but soon afterwards called up again as Italy entered the Second World War, joining the Italian Army as a medical officer.

His role eventually took him to the Russian front, where he suffered an injury to his shoulder that meant he was sent back to Italy to recuperate. Disillusioned with Mussolini and horrified at learning of the fate of Jews under Hitler, he decided not to return to the Army, joining the resistance instead. He stationed himself in a remote village outside Turin, tending to injured partisans.

After the war, he was briefly involved with politics, firstly on the Committee for National Liberation in Turin and then on the city council, but soon returned to Turin University to study physics and conduct biological research.

Dulbecco's fellow Turin University graduate
Salvador Duria also moved to America

With the encouragement of Levi-Montalcini, who would win a Nobel Prize in 1986 for her work in neurobiology, in 1946, he moved to United States, rejoining Luria, who shared a Nobel in 1969 for discoveries about the genetics of bacteria, at Indiana University, where they studied viruses. In the summer of 1949 he moved to Caltech, where he began his work on animal oncoviruses.

Dulbecco worked with Dr. Marguerite Vogt on a method of determining the amount of polio virus present in cell culture, a step that was vital in the development of polio vaccine, before becoming intrigued by a thesis written by Howard Temin on the connection between viruses and cancer.

He left Caltech in 1962 to move to the Salk Institute, a polio research facility in San Diego, and then in 1972 to the Imperial Cancer Research Fund (now Cancer Research UK) in London.

There was a mixed reaction in Italy when it was learned that ‘their’ Nobel Prize winner had become an American citizen. In fact, his Italian citizenship was revoked, although when he moved back to Italy in 1993 to spend four years as president of the Institute of Biomedical Technologies at National Council of Research in Milan he was made an honorary citizen.

Married twice, with three children, Dulbecco died in La Jolla, California, in 2012, three days before what would have been his 98th birthday.

From its elevated position, Catanzaro has views towards
the Ionian Sea and the resort of Catanzaro Lido

Travel tip:

Occupying a position 300m (980ft) above the Gulf of Squillace, Catanzaro is known as the City of the Two Seas because, from some vantage points, it is possible to see the Tyrrhenian Sea to the north of the long peninsula occupied by Calabria as well as the Ionian Sea to the south.  The historic centre, which sits at the highest point of the city, includes a 16th century cathedral built on the site of a 12th century Norman cathedral which, despite being virtually destroyed by bombing in 1943, has been impressively restored.  The city is about 15km (9 miles) from Catanzaro Lido, which has a long white beach typical of the Gulf of Squillace.

Hotels in Catanzaro by Booking.com

The waterfront of the Ligurian port city of Imperia, with
the Basilica of San Maurizio on top of the hill

Travel tip:

The beautiful city of Imperia, on Liguria's Riviera Poniente about 120km (75 miles) west of Genoa and 60km (37 miles) from the border with France, came into being in 1923 when the neighbouring ports of Porto Maurizio and Oneglia, either side of the Impero river, were merged along with several surrounding villages to form one conurbation.  Oneglia, once the property of the Doria family in the 13th century, has become well known for cultivating flowers and olives. Porto Maurizio, originally a Roman settlement called Portus Maurici, has a classical cathedral dedicated to San Maurizio, which was built by Gaetano Cantoni and completed in the early 19th century.

Stay in Imperia with Booking.com


More reading:

How Salvador Luria reached the United States after fleeing Paris on a bicycle

Grazia Deledda - the first Italian woman to win a Nobel Prize

The first physiologist to explain human movement

Also on this day:

1876: The birth of opera singer and director Giovanni Zenatello

1905: The birth of industrialist Enrico Piaggio

1921: The birth of actress Giulietta Masina

1990: The death of Autogrill pioneer Mario Pavesi

(Picture credits: Catanzaro view by Salvatore Migliari; Imperia waterfront by BMK)

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Gillo Pontecorvo - film director

Most famous film was banned in France

Gillo Pontecorvo was a journalist before being inspired
to make a career as a film director

The film director Gillo Pontecorvo, whose best known film, La battaglia di Algeri (The Battle of Algiers) won the Golden Lion at the Venice Film Festival in 1966 and was nominated for three Academy Awards, died on this day in 2006 in Rome, aged 86.

A former journalist who had been an Italian Resistance volunteer and a member of the Italian Communist Party, Pontecorvo had been in declining health for some years, although he continued to make documentary films and commercials until shortly before his death.

Although it was made a decade or so after the peak years of the movement, La battaglia di Algeri is in the tradition of Italian neorealism, with newsreel style footage and mainly non-professional actors.

Pontecorvo also won acclaim for his 1960 film Kapò, set in a Second World War concentration camp, and Burn! (1969) - titled Queimada in Italy - which was about the creation of a so-called banana republic on the fictitious Caribbean island of Queimada, starring Marlon Brando and loosely based on the failed slave revolution in Guadeloupe.

A poster for the US release of the
film La battaglia di algeri

Kapò, which was also was nominated for an Oscar, won a Italian National Syndicate of Film Journalists Silver Ribbon award for Didi Perego as best supporting actress, and the Mar del Plata Film Festival award for Susan Strasberg for best actress.

La battaglia di Algeri, which focussed on the Algerian War of Independence against the occupying French, caused great controversy in France, where it was banned for five years after the government objected to its sympathetic treatment of the Algerian rebels. Its co-star and joint producer, Saadi Yacef, was one of the leaders of the Algerian Liberation Front.

Pontecorvo was born in November 1919, in Pisa, into a high-achieving family. His father, Massimo, owned three textile factories employing more than 1,000 people. His eldest brother among seven siblings, Guido, later became an eminent geneticist, his second brother, Paolo, an engineer who worked on radar during the Second World War II and his third brother, Bruno, a renowned nuclear physicist.

Gillo enrolled at the University of Pisa to study chemistry but dropped out, taking the decision when Mussolini’s race laws came into force in 1938 to follow Bruno in fleeing to Paris, where he found work as a journalist.

When the German Army closed in on Paris, in June 1940, Pontecorvo and Bruno, along with their cousin Emilio Sereni, their friend, the future Nobel Prize-winning microbiologist Salvador Luria, and Pontecorvo’s future wife, Henrietta, fled the city on bicycles.

Marlon Brando played the lead character
in Pontecorvo's film Burn!

Pontecorvo reached St Tropez, where he earned money by drawing on his talent as a tennis player, providing lessons for rich residents.

By 1941, he had secretly joined the Italian Communist Party, and began to make regular trips to Italy to help organize anti-Fascist partisans.  Going by the pseudonym Barnaba, he spent the summer of 1943 working for his party’s underground newspaper, L'Unità, in Milan. From there he moved to Turin, where he began to organise factory workers.

After the war, he returned to Paris as the representative of Italy in the Youth World Federation and the Communist-backed World Federation of Democratic Youth.  Although his political philosophy remained Marxist, he broke his ties with the Communist party in 1956 after the Soviet intervention to suppress the Hungarian Revolution.

By then, his career as a filmmaker was established.  Although for many years an enthusiast for the cinema, it was after seeing Roberto Rossellini’s film, Paisà, that he gave up journalism and, using his own money and a 16mm camera, began to shoot political documentaries.

In 1957 he directed his first full-length film, La grande strada azzurra (The Wide Blue Road), which explored the life of a fisherman and his family facing hard times on a small island off the Dalmatian coast of Italy. The film won a prize at the Karlovy Vary International Film Festival.

Pontecorvo was director of
the Venice Film Festival 

Pontecorvo’s output was relatively small, largely because he spent months and sometimes years in research as he sought to produce authentic portrayals of events.

His last full-length feature film was Ogro (1979), which was inspired by the car bomb murder by ETA terrorists of Carrerro Blanco, the prime minister of Spain under Franco in 1973.  The film brought Pontecorvo his second David di Donatello award for Best Director, which he had also won for Burn! (Queimada).

Director of the Venice Film Festival from 1992 to 1994, Pontecorvo was married twice. His second wife, Teresa Ricci, bore him three sons - Ludovico, Marco and Simone.  Marco Pontecorvo followed his father’s footstep and became a filmmaker.

The Campo dei Miracoli in Pisa, with the baptistery in the
foreground and the Leaning Tower beyond the cathedral

Travel tip:

Pisa used to be one of Italy’s major maritime powers, rivalling Genoa and Venice, until silt deposits from the Arno river gradually changed the landscape and ultimately cut the city off from the sea in the 15th century. Nowadays, almost 15km (9 miles) inland, it is a university city renowned for its art and architectural treasures with a 10.5km (7 miles) circuit of 12th century walls. The Campo dei Miracoli, formerly known as Piazza del Duomo, located at the northwestern end of the city, contains the cathedral (Duomo), baptistery and famously the tilting campanile known as the Leaning Tower of Pisa, all built in black and white marble between the 11th and 14th centuries.

Giorgio Vasari's Palazzo della Carovana used to be the
headquarters of a Medici military order

Travel tip:

In the centre of Pisa, the elegant Piazza dei Cavalieri is dominated by Palazzo della Carovana, built and lavishly decorated by Giorgio Vasari between 1562 and 1564. Originally the headquarters of the Knights of St. Stephen, a Roman Catholic dynastic military order founded in 1561 by Cosimo I de' Medici, first Grand Duke of Tuscany, it is now the main building of the Scuola Normale Superiore di Pisa, one of three universities in Pisa, the others being the University of Pisa and the Scuola Superiore Sant’Anna.

More reading:

How Roberto Rossellini changed Italian cinema

Francesco Rosi - master of neorealism

The brilliance of Oscar-winner Vittorio de Sica

Also on this day:

1492: The death of Renaissance painter Piero della Francesca

1935: The birth of tenor Luciano Pavarotti


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Salvador Luria – microbiologist

Award winning scientist who advanced medical research

Salvador Luria, pictured at his desk at the Massachusetts
Institute of Technology at around the time of his Nobel Prize

Nobel prize winner Salvador Luria was born on this day as Salvatore Edoardo Luria in 1912 in Turin.

The microbiologist became famous for showing that bacterial resistance to viruses is genetically inherited and he was awarded a Nobel prize in 1969.

He studied in the medical school of the University of Turin and from 1936 to 1937 Luria served in the Italian army as a medical officer. He took classes in radiology at the University of Rome and began to formulate methods of testing genetic theory.

When Mussolini’s regime banned Jews from academic research fellowships, Luria moved to Paris but was forced to move again when the Nazis invaded France in 1940. Fearing for his life, he fled the capital on a bicycle, eventually reaching Marseille, where he received an immigration visa to the United States.

In America he met other scientists with whom he collaborated on experiments.  In 1943 Luria carried out an experiment with the scientist Max Delbruck that demonstrated that mutant bacteria can still bestow viral resistance without the virus being present.

Luria pictured with his American wife, Zella, at Cold
Spring Harbour, on the north shore of Long Island

He became chair of Microbiology at the Massachusetts Institute of Technology and received a number of awards and recognitions in addition to the Nobel prize.

Throughout his career, Luria was an outspoken political advocate. He protested against nuclear weapon testing, was an opponent of the Vietnam War and a supporter of organized labour.

Luria, an American citizen since 1947, died in Lexington, Massachusetts after a heart attack in 1991.

Travel tip:

Turin, the birth place of Luria, is the capital city of the region of Piedmont in the north of Italy. It is an important business centre, particularly for the car industry, and has a rich history linked with the Savoy Kings of Italy. Piazza Castello, with the royal palace, royal library and Palazzo Madama, which used to house the Italian senate, is at the heart of royal Turin.

The imposing main entrance to the Sapienza University
of Rome, built in the neoclassical style popular in the 1930s

Travel tip:

The University of Rome, where Luria studied, was founded in 1303 by Pope Boniface VIII.  Now known as the Sapienza University of Rome, it is one of the largest in Europe. The main campus, which was designed by Marcello Piacentini, is near Rome’s Termini railway station.

More reading:

Ernesto Teodoro Moneta - soldier who became a Nobel Peace Prize winner 

Dario Fo - critic of corruption who won Nobel Prize for Literature



(Photo of Rome University by Gongora CC BY-SA 4.0)

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