Piergiorgio Welby - euthanasia campaigner

Muscular dystrophy sufferer who fought for right to die

Piergiorgio Welby was kept alive by an artificial breathing
mechanism for the last nine years of his life

The poet, painter and muscular dystrophy sufferer Piergiorgio Welby, whose wish to be given help to die after nine years being kept alive artificially sparked a huge legal, political and religious debate, was born on this day in 1945 in Rome.

Welby, the son of an AS Roma footballer with Scottish ancestry, developed MS when he was 17 years old.

Throughout the 1960s and 70s his lifestyle helped keep the disease under control. He lived as an artist and writer, following the hippie movement but also hunting and fishing. His use of recreational drugs dulled the symptoms of the disease and he was able to travel extensively in Europe.

During this period he met his future wife, Wilhelmine - later known as Mina - who was from Bolzano province in Trentino-Alto Adige but encountered Welby in Rome.

Welby decided in the 1980s to wean himself off drugs by embarking on methadone therapy, but the disease then progressed rapidly and he was soon paralysed from the waist down.  In 1997, he suffered severe respiratory problems and from that point onwards was dependent on a breathing tube.  As well as mechanical ventilation, he depended on artificial feeding.

It was at this point he began to write and talk - he had a voice synthesizer - about euthanasia and joined the Italian Radical Party, the political organisation closest to his views.  In time, though, he lost even the ability to control a computer mouse.

Euthanasia was and remains illegal in Italy, largely due to the strict opposition of the Catholic Church, and though a patient has a right to refuse treatment, a doctor is still required to make every attempt to keep the patient alive.

Up to 1,000 people attended Piergiorgio Welby's secular
funeral in Piazza Don Bosco in the Tuscolano district

In September 2006, Welby sparked the political debate that was eventually to bring matters to a head by dictating an open letter to the Italian president, Giorgio Napolitano, which was shown on national television and reported extensively in the national press.

“I love life, Mr. President,” Welby wrote. “Life is the woman who loves you, the wind through your hair, the sun on your face, an evening stroll with a friend.

“Life is also a woman who leaves you, a rainy day, a friend who deceives you. I am neither melancholic nor manic-depressive. I find the idea of dying horrible. But what is left to me is no longer a life.”

Napolitano expressed his sympathy with Welby’s plight and invited politicians to debate the issue.

There were heated exchanges in the Italian parliament and political TV shows, around the political, ethical, religious and medical aspects of the case.

The Radical Party founder Marco Pannella said he was willing to turn off Welby’s life-support equipment himself as an "act of civil disobedience".

The outspoken Radical Party founder Marco
Pannella was a supporter of Welby's cause

Most Catholic politicians stood by the official position of the Catholic Church. Health Minister Livia Turco said that a parliamentary debate should focus more on improving palliative care rather than on euthanasia.

Welby’s right to refuse treatment under the Italian constitution and the code of conduct of Italian doctors was confirmed by a court ruling, but the doctor’s obligation to try to revive a patient in distress remained in place.

Eventually, an anaesthetist, Mario Riccio contacted the Radical Party and said he was prepared to switch off Welby’s life support, seeing no legal impediments. On December 20 he visited him in hospital in the presence of his wife Mina and daughter Carla and some supporters, including Marco Pannella, administered sedation and disconnected all the devices keeping him alive. He was pronounced dead 40 minutes later, at 11.40pm.

Welby’s death was announced the following morning by Pannella and a press conference followed later.

Luca Volonté, a Christian Democrat, called for Riccio to be arrested and charged with murder and had strong support in public opinion polls, but the the following March both the Ethical Committee of the Italian Medical Association and investigating magistrates declared Dr Riccio’s conduct to be lawful.

Controversially, the Catholic Church refused to allow Welby a religious funeral, declaring that his repeated public affirmations of his desire to end his own life were against Catholic doctrine.

Nonetheless, up to 1,000 people attended a secular funeral on December 24, 2006 in Piazza Don Bosco in the Tuscolano quarter of Rome, in front of the church that the family had chosen for the religious ceremony.

The town of San Candido is close to the Austrian border

Travel tip:

Mina Welby’s home town of San Candido, also known as Innichen, is in northern Italy, close to the border with Austria. It’s part of the Tre Cime Natural Park, in the Dolomites. Among the main sights in the historical centre is the Romanesque-style Innichen Abbey, with a frescoed dome, and the DoloMythos Museum, exploring local natural history. The area has a strong military history, being home to the Druso and Cantatore barracks, the latter housing the 6th Alpine Regiment of the Italian Army.  A short distance outside San Candido is a sanctuary where the bodies of more than 200 soldiers killed in the First World War were buried.

The Aqua Marcia aqueduct passes through the Tuscolano
quarter of Rome, along with several others

Travel tip:

Tuscolano is the 8th quartiere of Rome and is named after the Via Tuscolana that runs through it. It is one of the biggest districts of Rome, starting just outside the old city walls, near the Basilica of San Giovanni in Laterano, and stretches all the way to the Via del Quadraro in the east. Its northern border is the Via Casilina and its southern border is the Via Appia Nuova. The Via del Mandrione is lined by huge walls that supported five of the ancient Roman aqueducts - the Aqua Marcia, Aqua Tepula, Aqua Iulia, Aqua Claudia and the Anio Novus.


More reading:

Giorgio Napolitano - Italy's 11th President

Marco Pannella, the campaigner who helped shape modern Italy

Augusto Odone, inventor of 'Lorenzo's Oil'

Also on this day:

The Feast of Santo Stefano

1912: The birth of artist Renato Gattuso

1956: The birth of writer and journalist Beppe Severgnini


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Gaspare Tagliacozzi - surgeon

Professor invented rhinoplasty procedure

Gaspare Tagliacozzi perfected a way of
forming a new nose using skin from the arm

Pioneering plastic surgeon Gaspare Tagliacozzi died on this day in 1599 in Bologna.

During his career, Tagliacozzi had developed what became known as ‘the Italian method’ for nasal reconstruction.

He improved on the procedure that had been carried out by the 15th century Sicilian surgeons, Gustavo Branca, and his son, Antonio.

Tagliacozzi wrote a book, De Curtorum Chirugia per Insitionem - On the Surgery of Mutilation by Grafting - which described in great detail the procedures carried out in the past to repair noses amputated during battle.

Surgeons who came after him credit him with single-handedly revolutionising the procedure and inventing what is today referred to as a rhinoplasty procedure.

Tagliacozzi was born in Bologna in 1545. He studied medicine, natural sciences and anatomy at the University of Bologna, gaining a degree in philosophy and medicine by the age of 24.

After he was appointed professor of surgery and professor of anatomy at the University he taught at the Archiginnasio, famous for its anatomical theatre, where he procured the bodies of executed prisoners to use in dissections.

An illustration of a patient with arm
strapped in place across the nose

The operation for nasal reconstruction had been developed in Italy as early as the 15th century because of injuries sustained in battle, or when duelling using rapiers.

Tagliacozzi improved the reconstructive surgery method by taking skin from the arm using specially designed instruments to make the correct shape.

The flap of skin from the arm was attached to the nose and the patient’s arm was bandaged in the raised position for about 20 days, or until the skin of the arm had attached itself to the nose. The pedicle was then severed from the arm and after 14 days the attached skin was shaped so that it resembled a nose.

In his book explaining the procedure he writes: ‘We restore, rebuild and make whole those parts which nature hath given, but which fortune has taken away. Not so much that it may delight the eye, but that it might buoy up the spirit, and help the mind of the afflicted.’

Tagliacozzi died in Bologna on 7 November 1599 and was buried in the church of San Giovanni Battista de’ Celestini, as he had stipulated in his will. A solemn mass attended by doctors and colleagues was held in his honour later that month in the same church.

However, his body was later exhumed on the orders of the Catholic Church and reburied on unconsecrated ground, the church hierarchy having deemed that his surgery interfered with the handiwork of God.

After Tagliacozzi’s death, ‘the Italian method’ was not used again until the 19th century when a German plastic surgeon performed the procedure again.

Tagliacozzi also wrote a book about reconstructive surgery procedures for lips and ears.

The statue of Tagliacozzi in the
anatomical theatre of the Archiginnasio

Travel tip:

The world’s first university was established in Bologna in 1088 and attracted popes and kings as well as students of the calibre of Dante, Copernicus and Boccaccio. You can visit the university’s former anatomy theatre, where Tagliacozzi worked, in the oldest university building, the Archiginnasio, which is open to the public Monday to Saturday from 9 am to 1 pm, admission free. There is a wooden statue of Tagliacozzi holding a nose in his right hand, set in a niche in the wall of the anatomy theatre.

The church of San Giovanni Battista de'
Celestina in the centre of Bologna

Travel tip:

The church of San Giovanni Battista de’ Celestini in Bologna is a Renaissance-style Roman Catholic church located on Via D'Azeglio, where the Celestine order had built a monastery and church in the 14th century. In 1482, the church had become the home of the parish.It was rebuilt in 1535 on the site of a 13th century building in Piazza de’ Celestini.

More reading:

The 17th century anatomist whose work still benefits astronauts today

How Gabriele Falloppio made key discoveries about human reproduction

Italy's 18th century cataract surgeon

Also on this day:

The feast day of Ercolano, patron saint of Perugia

1512: Niccolò Machiavelli dismissed from office

1944: The birth of football legend Luigi Riva


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Guido Banti – physician

Doctor was the first to define leukaemia

Guido Banti was among the first doctors to
understand the disease process in leukaemia

The innovative physician and pathologist Guido Banti was born on this day in 1852 in Montebicchieri in Tuscany.

His work on the spleen led him to discover that a chronic congestive enlargement of the spleen resulted in the premature destruction of red blood cells. Closely related to leukaemia, this was later named 'Banti’s disease' in his honour.

Banti’s father was a physician and sent him to study medicine at the University of Pisa and the Medical School in Florence.

He graduated in 1877 and was appointed an assistant at the Hospital of Santa Maria Nuova and also as an assistant in the laboratory of Pathological Anatomy.

The ability to observe patients in bed and then carry out post mortem examinations was to prove fundamental to his work.

Within five years he had become chief of medical services. In 1895, after a five year spell in a temporary post he was appointed Ordinary Professor of Pathological Anatomy in the medical school in Florence. He remained in this post for 25 years.

Banti published the first textbook in Italy on the techniques of bacteriology in 1885.

Banti worked for a while at the Santa Maria Nuova Hospital,
the oldest still-active medical institution in Florence

He studied and also wrote about heart enlargement, the causes of aphasia and hyperplastic gastritis. He spent three years studying cancer cells and published a study of typhoid fever.

In 1895 he wrote about endocarditis and nephritis and atherosclerosis of the kidney.

He studied enlargement of the spleen and wrote a paper describing the condition that would become known as Banti’s disease. He proposed that the enlarged spleen was the cause of red cell destruction which led to anaemia and that only removal of the spleen could stop this process. On his advice, the first splenectomy for haemolytic jaundice was carried out in Florence in 1903.

Banti’s name is still primarily connected with leukaemia and he opposed the views of other scientists about the disease. In 1913 Banti decided that leukaemias are systemic diseases arising from the haematopoietic structures, bone marrow and lymph glands and are the result of the uncontrolled proliferation of staminal blood cells. This accords closely with the modern definition of leukaemia.

Banti died in Florence in 1935 aged 72.

The Church of Santa Lucia in Montebichieri

Travel tip:

Montebichieri, where Guido Banti was born, is a village to the southwest of San Miniato in the province of Pisa in Tuscany. In the centre of the village is the 14th century Church of Santa Lucia and a tower and parts of the original walls still survive from the medieval fortifications. Many of the houses are now empty and abandoned.

The bust of Guido Banti at
the Florence Institute

Travel tip:

There is a bust of Guido Banti in the Institute of Anatomy and Pathology in Florence.  The Institute, established in 1824, is famous for its collection of wax pathological models created in the 19th century, which were invaluable teaching tools in medical schools, where living examples, cadavers, and other visual aids of many pathologies were often scarce. One of the most famous pieces in the museum is the 1851 “leper” model by artist Luigi Calamai.  The museum, which was originally housed at the University of Florence, was moved to the city’s Careggi Hospital in 1859.

Also on this day:

1671: The birth of Venetian composer Tomaso Albinoni

1823: The birth of Pompeii archaeologist Giuseppe Fiorelli

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Andrea Verga - anatomist and neurologist

Professor among founding fathers of Italian psychiatry

Andrea Verga was one of the first to see how criminal
behaviour could be driven by insanity

The anatomist and neurologist Andrea Verga, who was one of the first Italian doctors to carry out serious research into mental illness, was born on this day in 1811 in Treviglio in Lombardy.

Verga’s career was notable for his pioneering study of the criminally insane, for some of the first research into acrophobia - the fear of heights - which was a condition from which he suffered, and for the earliest known experiments in the therapeutic use of cannabis.

For a number of years, he held the post of Professor of Psychiatry at the Ospedale Maggiore in Milan. He also founded, in conjunction with another physician, Serafino Biffi, the Italian Archives for Nervous Disease and Mental Illness, a periodical in which research findings could be shared and discussed.

Verga also acquired an in-depth knowledge of the anatomy of the bone system and the nervous system, and was the first to identify an anomaly of the brain that occurs in only one in six people, which became known as ‘Verga’s ventricle’.

The son of a coachman, Verga was an enthusiastic student of classics whom his parents encouraged to pursue a career in the church, yet it was medicine that became his calling.  He went to the University of Pavia, graduating in 1832 and becoming assistant to Bartolomeo Panizza, whose previous students had included Italy’s first Nobel Prize winner, Camillo Golgi.

Verga was a driving force behind Milan's Provincial
Psychiatric Hospital at Mombello 

Verga spent much of his working life with sight in only one eye, the consequence, it might be said, of his failing to remember to take literally the biblical proverb ‘physician heal thyself’. During an outbreak of cholera, in which he attended many sick patients, he developed a serious eye infection, which he neglected to treat, and went blind in the affected eye.

Nonetheless, steering himself towards the field of psychiatry and mental illness, in 1843 he moved to Milan, where he worked at the private hospital of San Celso, which cared for mental patients from the city’s wealthier classes.

While working at San Celso, he is thought to have participated with other physicians in experiments on the therapeutic use of cannabis in mental health conditions. The plant had a history of medical use in a number of ancient civilisations.

In 1848, amid the chaos of the first Italian War of Independence, he became the director of the Pia Casa della Senavra, Milan’s first public mental hospital. For several years his movements came under the scrutiny of the occupying Austrians, yet in 1852 he was offered the chance to lead psychiatric research at the city’s Ospedale Maggiore.

Andrea Verga's tomb at the Monumental Cemetery in Milan

There he pushed for reforms that fundamentally improved the service of medicine and surgery in Milan. With Biffi he helped construct a more accurate definition of the symptoms of mental illness and the concept of insanity, and its recognition as grounds for a different interpretation, in some cases, of criminal behaviour.

Also, along with Biffi and Cesare Castiglioni, he argued the need for a more modern mental hospital in Milan. His arguments were rewarded when Senevra was closed and replaced, in 1878, by the Provincial Psychiatric Hospital of Milan at Mombello. 

Devoted to his work throughout his life, Verga never married. He did find time to become involved in local politics, however, as a councillor and in 1876 was appointed a Senator of the Kingdom of Italy.

He died in 1895 and was buried in the Monumental Cemetery in Milan.

The Basilica of San Martino in Treviglio

Travel tip:

The small city of Treviglio in Lombardy, where Verga was born, is about 20km (13 miles) south of Bergamo and 41km (26 miles) northeast of Milan. It developed from a fortified town in the early Middle Ages and, having been at times controlled by the French and the Spanish, became part of the Kingdom of Italy in 1860.  Its most visited attraction is the Basilica of San Martino, originally built in 1008 and reconstructed in 1482, with a Baroque façade from 1740, which is in Piazza Luciano Manara. Opposite the basilica is the historic Caffè Milano, founded in 1896, which retains the original turn-of-the century furniture and a counter in Art Nouveau style.

The bust of Andrea Verga in Largo
Francesco Richini in Milan

Travel tip:

An enormous white marble bust, dedicated in 1903 to Andrea Verga, can be found in Largo Francesco Richini in the centre of Milan, opposite what was formerly the Ospedale Maggiore, which is now part of the campus of the University of Milan, created by the Milan sculptor Giulio Branca. The Ospedale Maggiore moved early in the 20th century to a vast new site not far away, opposite the university buildings on the other side, bordered by Via Francesco Sforza.

Also on this day:

1875: The birth of Giovanni Gentile, the so-called 'philosopher of Fascism' 

1924: The day tragic politician Giacomo Matteotti spoke out against Fascist thugs

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Hieronymus Fabricius - anatomist and surgeon

Research pioneer known as “Father of Embryology”

Girolamo Fabrizio spent much of his academic
life at the University of Padua

The pioneering anatomist and physiologist known in academic history as Hieronymus Fabricius, whose Italian name was Girolamo Fabrizio, was born on this day in 1537 in Acquapendente, in Lazio.

Fabrizio, who designed the first permanent theatre for public anatomical dissections, advanced the knowledge of the make-up of the human body in many areas, including the digestive system, the eyes and ears, and the veins.

But his most significant discoveries were in embryology.  He investigated the foetal development of many animals and humans and produced the first detailed description of the placenta. For this he became known as the "Father of Embryology".

Fabrizio spent most of his life at the University of Padua, where he was a student under the guidance of Gabriele Falloppio, who discovered the tube connecting the ovaries with the uterus that became known as the Fallopian tube.

He succeeded Falloppio as chair of surgery and anatomy, holding the post from 1562 to 1613 and building a reputation that attracted students from all of Europe.

Among his pupils were the English anatomist William Harvey, as well as Giulio Casseri and Adriaan van den Spiegel, both of whom went on to become significant anatomists in Italy. Indeed, both also occupied the chair of surgery and anatomy at the University of Padua.

The Teatro Anatomico at the University of Padua was
designed by Girolamo Fabrizio

Fabrizio’s dissections of animals enabled him to make discoveries about the formation of the fetus, the structure of the esophagus, stomach and intestines, and the workings of the eye, the ear, and the larynx. He was the first to note that the pupil of the eye changes in size.

He was the first to identify the membranous folds that he called "valves" in the interior of veins, which are now understood to prevent retrograde flow of blood within them.

Fabrizio also described the cerebral fissure separating the temporal lobe from the frontal lobe of the brain, although it is only recently that he has been credited with the discovery.

The statue of Girolamo Fabrizio in
his home town of Acquapendente

He was a practising surgeon as well as an anatomist. Extraordinarily, the technique he invented to perform a tracheotomy is very similar to the procedure used in the operation today.

Fabrizio never actually performed such an operation himself, but in his writing he described using a vertical incision and a tracheostomy tube, a short, straight cannula to which he added wings to prevent the tube from disappearing into the trachea.

The technique may have been used for the first time by the surgeon Marco Aurelio Severino during a diptheria epidemic in Naples in 1610.

Fabrizio died in Padua in 1619 at the age of 82. There is a monument to him in his home town of Acquapendente.

The castle at Torre Alfina, near Acquapendente

Travel tip:

Acquapendente is a medieval town in northern Lazio, about 140km (87 miles) north of Rome, just under 30km (18 miles) west of Orvieto. It takes its name - literally translated as ‘hanging water’ - from the small waterfalls that flow into the Paglia river. Among the main sights is the Duomo di Acquapendente, which developed from a former Benedictine monastery, developed in the 12th century. A short distance from Acquapendente is he castle of Torre Alfina, the central tower of which was built by the Lombard king Desiderius.

Palazzo Bo, the historic home of the University of Padua

Travel tip:

The founding of the University of Padua is officially recorded to have taken place in 1222 but this was actually the first time it was mentioned in an historical document, which means it is certainly older. It was formed when a large group of students and professors left the University of Bologna in search of more academic freedom. The first subjects to be taught were law and theology.

Also on this day:

1470: The birth of the poet Pietro Bembo, lover of Lucrezia Borgia

1943: The birth of the veteran singer Al Bano

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Pietro Andrea Mattioli – doctor

The first botanist to describe the tomato

As a physician, Pietro Andrea Mattioli described the
first documented case of cat allergy

Doctor and naturalist Pietro Andrea Gregorio Mattioli was born on this day in 1501 in Siena.

As the author of an illustrated work on botany, Mattioli provided the first documented example of an early variety of tomato that was being grown and eaten in Europe.

He is also believed to have described the first case of cat allergy, when one of his patients was so sensitive to cats that if he went into a room where there was a cat he would react with agitation, sweating and pallor.

Mattioli received his medical degree at the University of Padua in 1523 and practised his profession in Siena, Rome, Trento and Gorizia.

He became the personal physician to Ferdinand II, Archduke of Austria, in Prague and to Maximilian II, Holy Roman Emperor, in Vienna.

While working for the imperial court it is believed he tested the effects of poisonous plants on prisoners, which was a common practice at the time.

Mattioli's book about the work of
Greek physician Dioscorides

Mattioli’s interest in botany led him to describe 100 new plants and document the medical botany of his time in his Discorsi (Commentaries) on the Materia Medica of Dioscorides, a Greek physician and botanist. Dioscorides had written a five-volume encyclopaedia about herbal medicine and other medicinal substances that had been widely read for 1,500 years.

The first edition of Mattioli’s work appeared in 1544 in Italian. There were several later editions and translations into Latin, French, Czech and German.

He added descriptions of plants not in the original work and not of any known medical use. The woodcuts in Mattioli’s work were of a high standard, helping the reader to identify the plants.

The Scottish botanist Robert Brown later named a plant genus Matthiola in his honour.

Mattioli died in 1577 during a visit to Trento, now the capital city of Trentino-Alto Adige.

Siena's Piazza del Campo viewed from the air

Travel tip:

Mattioli’s birthplace, Siena, is famous for its shell-shaped Piazza del Campo, where the Palio di Siena takes place twice each year. It was established in the 13th century as an open marketplace and is now regarded as one of the finest medieval squares in Europe. The red brick paving, fanning out from the centre in nine sections, was put down in 1349. The city’s Duomo was designed and completed between 1215 and 1263 on the site of an earlier structure. It has a beautiful façade built in Tuscan Romanesque style using polychrome marble.

The Piazza del Duomo in Trento

Travel tip:

Trento is a city on the Adige river, which was formerly part of Austria-Hungary. It is famous as the location of the Council of Trent in the 16th century, an ecumenical council that led to a Catholic resurgence in the wake of the Protestant Reformation.  It was annexed by Italy in 1919 and is now one of the country’s most prosperous cities.

Hotels in Trento from Booking.com



More reading:

Ulisse Aldrovandi - the 'father' of natural history

How Prospero Alpini 'discovered' the coffee-drinking habit that took Italy by storm in the 18th century

Cesare Battisti - the patriot who campaigned for Trentino

Also on this day:

1863: The birth of writer and patriot Gabriele D'Annunzio

1921: The birth of Fiat patriarch Gianni Agnelli

(Picture credit: Piazza del Duomo by Casalmaggiore Provincia via Wikimedia Commons)

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Augusto Odone – medical pioneer

Father who invented ‘Lorenzo’s Oil’ for sick son

Augusto Odone devoted his life to caring
for his stricken son Lorenzo

Augusto Odone, the father who invented a medicine to treat his incurably ill son despite having no medical training, was born on this day in 1933 in Rome.

Odone’s son, Lorenzo, was diagnosed with the rare metabolic condition ALD (Adrenoleukodystrophy) at the age of six. Augusto and his American-born wife, Michaela, were told that little could be done and that Lorenzo would suffer from increasing paralysis and probably die within two years.

Refusing simply to do nothing, the Odones, who lived in Washington, where Augusto was an economist working for the World Bank, threw themselves into discovering everything that was known about the condition and the biochemistry of the nervous system, contacting every doctor, biologist and researcher they could find who had researched the condition and assembled them for a symposium.

Drawing on this pooled knowledge, and with the help of Hugo Moser, a Swiss-born professor of neurology at Johns Hopkins University in Baltimore, they eventually came up with the idea of combining extracts of olive oil and rapeseed oil in a medicine that would break down the long-chain fatty acids in the human body that were considered a major cause of the nerve damage suffered by people with ALD.

The medicine, which seemed to slow the progression of Lorenzo’s disease, soon became known as Lorenzo’s Oil. Against all odds, Lorenzo survived until the day after his 30^th birthday, having lived more than 20 years beyond his doctors’ gloomy forecasts.

Lorenzo (left), with his father, lived for 22 years longer
 than doctors predicted after his diagnosis

The Odones, moreover, were convinced that Lorenzo drew some pleasure from being alive. He showed signs that he enjoyed music and listening to stories and responded to voices, even though for the last 22 years of his life he was paralysed, blind and unable to speak, could only be fed through a tube and required round-the-clock nursing care. He communicated by blinking and wiggling his fingers.

Their story attracted attention all over the world.  It became the subject of a film, entitled Lorenzo’s Oil, directed by George Miller and starring Nick Nolte and Susan Sarandon, that was a box office hit and was nominated for two Academy Awards.

The movie attracted criticism from medical experts for portraying scientists as unfeeling, although the Odones had been outspoken in their comments about the response of the medical establishment to their attempts to find a treatment.

Doctors also criticised the film for suggesting that Lorenzo’s Oil was a cure for ALD, although the medicine is still used today and has been shown to delay the onset of symptoms if prescribed before they develop.

Lorenzo seemed a normal
child until the age of four

Augusto Odone, whose mother was a novelist and his father a general in the Italian army, grew up in Gamalero, a village in Piedmont, not far from Alessandria.  He was educated at the University of Rome before attending the University of Kansas on a scholarship.  He joined the World Bank in 1969.

He devoted much of his life to raising money for research before deciding in 2010, two years after Lorenzo’s death, to move back to Italy, settling in Acqui Terme, about 20km (12 miles) from Gamalero.  He died there in 2013, aged 80, having survived Michaela, his second wife, by 13 years.

His daughter by his first marriage is the Kenyan-born English journalist and novelist, Christina Odone.

La Bollente in Acqui Terme

Travel tip:

Acqui Terme in Piedmont, which is situated about 100km (62 miles) southeast of Turin, is a town of just over 20,000 people best known for the local wine, Brachetto d’Acqui, and for the hot sulphur springs that were discovered during the Roman era, which bubble up at a temperature of 75 degrees Celsius, emerging at a site in the centre of the town where a small pavilion, called La Bollente, was built in 1870.

Hotels in Acqui Terme by Booking.com

Travel tip:

Alessandria, a city of 94,000 people about equidistant from Turin and Milan, is notable for the Cittadella, the 18^th century star fort across the Tanaro river from the city, which is one of the best preserved fortifications of that era, with the outer wall and defensive towers still intact.  It is also home to a military museum that contains more than 1500 uniforms, weapons and other memorabilia from the Italian Army.

Find a hotel in Alessandria with Tripadvisor

More reading:

How Renato Dulbecco's research led to greater understanding of cancer

The first physiologist to explain human movement

Camillo Golgi - the greatest nueroscientist of the 19th century

Also on this day:

1483: The birth of historian Francesco Guicciardini

1853: Verdi's La Traviata is performed for the first time

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Giovanni Battista Morgagni - anatomist

The father of modern pathological anatomy

Giovanni Battista Morgagni taught at the
University of Padua for 56 years

Anatomist Giovanni Battista Morgagni, who is credited with turning pathology into a science, was born on this day in 1682 in Forlì in Emilia-Romagna.

Morgagni was professor of Anatomy at the University of Padua for 56 years and taught thousands of medical students during his time there.

He was sent by his parents to study philosophy and medicine at the University of Bologna when he was 18 and he graduated as a doctor from both faculties.

In 1706 he published his work, Adversaria Anatomica, which was to be the first volume of a series and helped him become known throughout Europe as an accurate anatomist.

He succeeded to the chair of theoretical medicine at the University of Padua in 1712 and was to teach medicine there until his death in 1771.

Morgagni was promoted to the chair of anatomy after his first three years in Padua, following in the footsteps of many illustrious scholars. He brought out five more volumes of his Adversaria Anatomica during his early years in Padua.

Morgagni's Adversaria Anatomica helped
establish his reputation

In 1761, when he was nearly 80, he brought out the work that was to make pathological anatomy into a science – De Sedibus et causis morborum per anotomem indagatis (Of the seats and cause of diseases investigated through anatomy). This work, which contained the records of 646 dissections, was later reprinted several times in its original Latin and translated into French, English and German.

Morgagni was the first anatomist to understand and to demonstrate the absolute necessity of basing diagnosis, prognosis and treatment on an exact and comprehensive knowledge of anatomical conditions. His precision, thoroughness and freedom from bias are modern scientific qualities and he was also a widely respected clinician who maintained an active practice. His treatise was to lead to steady progress in pathology and practical medicine.

Morgagni had married a noble lady from Forlì during his early years in Padua who bore him three sons and 12 daughters. He died at the age of 89 in Padua.

He is today regarded as the father of modern pathological anatomy as his works helped to make it into an exact science.

Forlì's Palazzo Poste e Telegrafi in Piazza Saffi

Travel tip:

Forlì, where Morgagni was born, is today a prosperous city with a beautiful main square, Piazza Saffi, named after Aurelio Saffi, a radical republican who was a prominent figure in the Risorgimento. The square is dominated by the monumental Palazzo Poste e Telegrafi, designed by Cesare Bazzani in 1932 to celebrate the Fascist regime. Benito Mussolini was born in nearby Predappio and blatantly favoured the area of his birth with imposing new buildings.

Hotels in Forlì from Booking.com

Palazzo del Bò in the centre of the city is the
main building of the University of Padua

Travel tip:

The University of Padua, where Morgagni taught for most of his life, was established in 1222 and is one of the oldest in the world, second in Italy only to the University of Bologna. The main university building, Palazzo del Bò in Via VIII Febbraio in the centre of Padua, used to house the medical faculty. You can take a guided tour to see the pulpit used by Galileo when he taught at the university between 1592 and 1610.


More reading:

Paolo Mascagni, the first physician to map the human lymphatic system

How Gabriele Falloppio made key discoveries about human reproduction

Hieronymus Fabricius, the father of embyology

Also on this day:

1707: The birth of playwright Carlo Goldoni

1873: The birth of the great operatic tenor Enrico Caruso

2003: The death of comic actor Alberto Sordi


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Paolo Mascagni – physician

Scientist was first to map the human lymphatic system

Paolo Mascagni studied geology before turning
to human science and anatomy

The physician Paolo Mascagni, whose scientific research enabled him to create the first map of the complete human lymphatic system, was born on this day in 1755 in Pomarance, a small town in Tuscany about 40km (25 miles) inland from the western coastline.

Mascagni described his findings in a book with detailed illustrations of every part of the lymphatic system he had identified, which was to prove invaluable to physicians wanting to learn more about a part of the human body vital to the regulation of good health.

He also commissioned the sculptor Clemente Susini to create a full-scale model in wax of the lymphatic system, which can still be seen at the Museum of Human Anatomy at the University of Bologna.

Later he created another significant tome, his Anatomia Universa, which comprises 44 enormous copperplate illustrations that set out to bring together in one book the full extent of human knowledge about the anatomy of the human body.  The ‘book’ in the event was so large it was never bound, each plate measuring more than 3ft 6ins (1.07m) by 2ft 6ins (0.76m), designed in such a way that those from the same plane of dissection can be placed together and show the whole body in life size.

Mascagni was the son of Aurelio Mascagni and Elisabetta Burroni, both belonging to ancient noble families from Chiusdino, a village in the province of Siena.

An illustration from Mascagni's celebrated
book on the human lymphatic system

He studied at the University of Siena, where his teacher of anatomy was Pietro Tabarrini, and graduated in philosophy and medicine in 1771. By his final year, he had been appointed assistant to Tabarrini and succeeded his mentor as Professor of Anatomy after blindness forced him to retire.

As a young man, Mascagni had been keen on geology and wrote a number of papers on the thermal springs of Siena and Volterra. Later, he would successfully identify boric acid in the waters and suggest ways to produce from it the industrial compound now known as borax.

After graduating, his focus turned to the human lymphatic system, feeling that he owed it to Tabarrini to do what he could to advance his teacher’s research into the workings of the human body. He decided that he would not work in clinical medicine but devote himself entirely to teaching and research.

His work was interrupted for a while by the political upheaval of the late 18^th century, when Tuscany was occupied by the French. He became involved in politics somewhat reluctantly, becoming Superintendent of the Arts, Sciences and Charitable Institutions of Siena, and this placed him in constant conflict with the French authorities over their seizing of personal and public property.

Unfortunately, his involvement with the French was misinterpreted when Austria regained control of the area. Accused of having Jacobin sympathies, he was arrested and imprisoned for seven months.

The statue of Mascagni in the courtyard of the
Uffizi in Florence, where he lived for some years

On his release, he was appointed a professor of anatomy at the University of Pisa and began lecturing at the Hospital of Santa Maria Nuova in Florence before becoming a full professor at the University of Florence.

In his research into the lymphatic system, Mascagni perfected a technique whereby he injected mercury as a contrast medium into the peripheral lymphatic networks of a human cadaver and by following the mercury’s flow to other parts of the system was able to produce detailed diagrams and models.

This brought him fame all over Europe, yet he did not limit himself to merely describing the anatomy of the lymphatic system.  By his research into its physiology and pathology he was able to highlight its importance in fighting disease in the human body, the understanding of which helped in the evolution of new treatments.

Mascagni died in 1815 during a stay at his estate in Castelletto, near Chiusdino, the village near Siena where his family originated and where he spent most of his free time. He had contracted a pernicious fever, probably malaria.

His memory has been commemorated in several ways. The street where he was born in Pomerance is now called Via Paolo Mascagni; the hamlet where the family lived, 33km (20 miles) southwest of Siena, is now known as Castelletto Mascagni, and there is another Via Paolo Mascagni in nearby Chiusdino.

A statue of Paolo Mascagni can be found in a niche in the courtyard of the Uffizi in Florence, as one of the great men of Tuscany.  His house in Florence was in Via Fiesolana.  There is also a monument to him in the Accademia dei Fisiocritici in Siena, of which he was president.

One of the medieval gates into the town of Pomarance

Travel tip:

The town of Pomarance, where Mascagni was born, sits on a hill overlooking Val di Cecina, on the border between the provinces of Pisa, 80km (50 miles) to the north, and Siena, 69km (43 miles) to the east. The main square, Piazza de Larderel, is named after Francois Jacques de Lardarel, a 19^th century French engineer who worked in the area on the exploitation of geothermal energy from the steam emitted by lagoons in the area.

The ancient village of Chiusdino occupies a hilltop position

Travel tip:

The ancient village of Chiusdino dates back to the seventh or eighth century, when it was a Longobard settlement, sitting on the top of a hill, surrounded by walls. Much of the history of the town surrounds the legend of San Galgano, who was an arrogant, licentious son of a local feudal lord in the 12^th century who changed his ways after a supposed visit from Saint Michael the Archangel, who told him he must give up his excesses, prompting Galgano to say it would be easier to cut a rock with a sword. As if to prove it, he launched a sword thrust at a rock and was amazed when the blade plunged into the rock as easily as a knife into butter. He knelt to pray and vowed to become a hermit. The sword in the rock remains on display in a chapel, the Rotonda della Spada, that was built around it.

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Camillo Golgi – neuroscientist

Nobel prize winner whose name lives on in medical science

Camillo Golgi expanded knowledge of
the human nervous system

Camillo Golgi, who is recognised as the greatest neuroscientist and biologist of his time, died on this day in 1926 in Pavia.

He was well known for his research into the central nervous system and discovering a staining technique for studying tissue, sometime called Golgi’s method, or Golgi’s staining.

In 1906, Golgi and a Spanish biologist, Santiago Ramon y Cajal, were jointly awarded the Nobel Prize in Physiology or Medicine in recognition of their work on the structure of the nervous system.

Golgi was born in 1843 in Corteno, a village in the province of Brescia in Lombardy.

The village was later renamed Corteno Golgi in his honour.

In 1860 Golgi went to the University of Pavia to study medicine. After graduating in 1865 he worked in a hospital for the Italian army and as part of a team investigating a cholera epidemic in the area around Pavia.

He resumed his academic studies under the supervision of Cesare Lombroso, an expert in medical psychology, and wrote a thesis about mental disorders. As he became more and more interested in experimental medicine he started attending the Institute of General Pathology headed by Giulio Bizzozero, who was to influence Golgi’s research publications. They became close friends and Golgi later married his niece, Lina Aletti.

Financial pressure led Golgi to work at the Hospital for the Chronically Ill in Abbiategrasso near Milan and while he was there he set up a simple laboratory in a former hospital kitchen.

A statue within the campus of Pavia University
commemorates Golgi's life and work

It was in his improvised laboratory that he made his most notable discoveries. His major achievement was the development of staining technique for studying nerve tissue called the black reaction, using potassium bichromate and silver nitrate, which was more accurate than other methods and was later to become known as Golgi’s method.

In 1885 he joined the faculty of histology at the University of Pavia and then later became Professor of Histology. He also became Professor of Pathology at the San Matteo hospital.  His connection with the university is commemorated with a statue within the grounds, while a plaque marks the house in nearby Corso Strada Nuova where he lived.

He was rector of the University of Pavia for two separate periods and during the First World War he directed the military hospital, Collegio Borromeo, in Pavia.

Golgi retired in 1818 and continued his research in a private laboratory. He died on 21 January1926.

In 1900 he had been named as a Senator by King Umberto I. He received honorary doctorates from many universities and was commemorated on a stamp by the European community in 1994.

The Golgi apparatus, the Golgi tendon organ, the Golgi tendon reflex and certain nerve cells are all named after him.

The Golgi museum in Via Brescia, Corteno Golgi

Travel tip:

Corteno Golgi, a village of around 2,000 people is situated in the High Camonica Valley, about 100km (62 miles) north of Brescia in the Orobie Alps in Lombardy. It has a museum dedicated to Camillo Golgi in Via Brescia. For more information visit www.museogolgi.it.

The covered bridge over the Ticino river at Pavia

Travel tip:

Pavia, where Golgi lived for a large part of his life, is a city in Lombardy, about 46km (30 miles) south of Milan, known for its ancient university, which was founded in 1361, and its famous Certosa, a magnificent monastery complex north of the city that dates back to 1396. A pretty covered bridge over the River Ticino leads to Borgo Ticino, where the inhabitants claim to be the true people of Pavia and are of Sabaudian origin.

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