Paolo Mascagni – physician

Scientist was first to map the human lymphatic system

Paolo Mascagni studied geology before turning
to human science and anatomy

The physician Paolo Mascagni, whose scientific research enabled him to create the first map of the complete human lymphatic system, was born on this day in 1755 in Pomarance, a small town in Tuscany about 40km (25 miles) inland from the western coastline.

Mascagni described his findings in a book with detailed illustrations of every part of the lymphatic system he had identified, which was to prove invaluable to physicians wanting to learn more about a part of the human body vital to the regulation of good health.

He also commissioned the sculptor Clemente Susini to create a full-scale model in wax of the lymphatic system, which can still be seen at the Museum of Human Anatomy at the University of Bologna.

Later he created another significant tome, his Anatomia Universa, which comprises 44 enormous copperplate illustrations that set out to bring together in one book the full extent of human knowledge about the anatomy of the human body.  The ‘book’ in the event was so large it was never bound, each plate measuring more than 3ft 6ins (1.07m) by 2ft 6ins (0.76m), designed in such a way that those from the same plane of dissection can be placed together and show the whole body in life size.

Mascagni was the son of Aurelio Mascagni and Elisabetta Burroni, both belonging to ancient noble families from Chiusdino, a village in the province of Siena.

An illustration from Mascagni's celebrated
book on the human lymphatic system

He studied at the University of Siena, where his teacher of anatomy was Pietro Tabarrini, and graduated in philosophy and medicine in 1771. By his final year, he had been appointed assistant to Tabarrini and succeeded his mentor as Professor of Anatomy after blindness forced him to retire.

As a young man, Mascagni had been keen on geology and wrote a number of papers on the thermal springs of Siena and Volterra. Later, he would successfully identify boric acid in the waters and suggest ways to produce from it the industrial compound now known as borax.

After graduating, his focus turned to the human lymphatic system, feeling that he owed it to Tabarrini to do what he could to advance his teacher’s research into the workings of the human body. He decided that he would not work in clinical medicine but devote himself entirely to teaching and research.

His work was interrupted for a while by the political upheaval of the late 18^th century, when Tuscany was occupied by the French. He became involved in politics somewhat reluctantly, becoming Superintendent of the Arts, Sciences and Charitable Institutions of Siena, and this placed him in constant conflict with the French authorities over their seizing of personal and public property.

Unfortunately, his involvement with the French was misinterpreted when Austria regained control of the area. Accused of having Jacobin sympathies, he was arrested and imprisoned for seven months.

The statue of Mascagni in the courtyard of the
Uffizi in Florence, where he lived for some years

On his release, he was appointed a professor of anatomy at the University of Pisa and began lecturing at the Hospital of Santa Maria Nuova in Florence before becoming a full professor at the University of Florence.

In his research into the lymphatic system, Mascagni perfected a technique whereby he injected mercury as a contrast medium into the peripheral lymphatic networks of a human cadaver and by following the mercury’s flow to other parts of the system was able to produce detailed diagrams and models.

This brought him fame all over Europe, yet he did not limit himself to merely describing the anatomy of the lymphatic system.  By his research into its physiology and pathology he was able to highlight its importance in fighting disease in the human body, the understanding of which helped in the evolution of new treatments.

Mascagni died in 1815 during a stay at his estate in Castelletto, near Chiusdino, the village near Siena where his family originated and where he spent most of his free time. He had contracted a pernicious fever, probably malaria.

His memory has been commemorated in several ways. The street where he was born in Pomerance is now called Via Paolo Mascagni; the hamlet where the family lived, 33km (20 miles) southwest of Siena, is now known as Castelletto Mascagni, and there is another Via Paolo Mascagni in nearby Chiusdino.

A statue of Paolo Mascagni can be found in a niche in the courtyard of the Uffizi in Florence, as one of the great men of Tuscany.  His house in Florence was in Via Fiesolana.  There is also a monument to him in the Accademia dei Fisiocritici in Siena, of which he was president.

One of the medieval gates into the town of Pomarance

Travel tip:

The town of Pomarance, where Mascagni was born, sits on a hill overlooking Val di Cecina, on the border between the provinces of Pisa, 80km (50 miles) to the north, and Siena, 69km (43 miles) to the east. The main square, Piazza de Larderel, is named after Francois Jacques de Lardarel, a 19^th century French engineer who worked in the area on the exploitation of geothermal energy from the steam emitted by lagoons in the area.

The ancient village of Chiusdino occupies a hilltop position

Travel tip:

The ancient village of Chiusdino dates back to the seventh or eighth century, when it was a Longobard settlement, sitting on the top of a hill, surrounded by walls. Much of the history of the town surrounds the legend of San Galgano, who was an arrogant, licentious son of a local feudal lord in the 12^th century who changed his ways after a supposed visit from Saint Michael the Archangel, who told him he must give up his excesses, prompting Galgano to say it would be easier to cut a rock with a sword. As if to prove it, he launched a sword thrust at a rock and was amazed when the blade plunged into the rock as easily as a knife into butter. He knelt to pray and vowed to become a hermit. The sword in the rock remains on display in a chapel, the Rotonda della Spada, that was built around it.

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Vajont Dam Disaster

Catastrophic flood may have killed 2,500

The Vajont Dam, pictured before the disaster of 1963, was
considered a triumph of  engineering.

Prone to earthquakes because of its unfortunate geology, Italy has suffered many natural disasters over the centuries, yet the horrific catastrophe that took place on this day 53 years ago in an Alpine valley about 100km north of Venice, killing perhaps as many as 2,500 people, was to a significant extent man-made.

The Vajont Dam Disaster of October 9, 1963 happened when a section of a mountain straddling the border of the Veneto and Fruili-Venezia Giulia regions in the Fruilian Dolomites collapsed in a massive landslide, dumping 260 million cubic metres of forest, earth and rock into a deep, narrow reservoir created to generate hydroelectric power for Italy's industrial northern cities.

The chunk of Monte Toc that came away after days of heavy rain was the size of a small town yet within moments it was moving towards the water at 100km per hour (62mph) and hit the surface of the reservoir in less than a minute.

The effect was almost unimaginable.  Within seconds, 50 million cubic metres of water was displaced, creating a tsunami that rose to 250m high.  The dam held, but the colossal volume of water had nowhere to go but over the top and into the Piave valley below.

Where the village of Longarone had stood, all that
 remained was mud and debris.

The landslide was timed at 10.39pm.  In the valley, dotted with villages, many residents were already in bed, others locking up, some making their way home.  They had no chance of escape.  The only warning was a rumbling in the distance, accompanied by a sudden, strengthening wind, that rapidly turned into a deafening roar.

The force behind the surge of water was such that its initial impact with the valley floor after its 250m descent through the narrow Vajont gorge left a crater 60m (200ft) deep and 80m across.

As the water rushed onwards into the Piave valley, it pushed along a pocket of air generating more energy than was created by the atomic bomb that flattened Hiroshima. It was so powerful that most of the victims were found naked, their clothes ripped off them by the blast.

Within a matter of minutes, the villages of Longarone, Pirago, Rivalta, Villanova and Faè had been wiped from the map and 80 per cent of their inhabitants were dead, accounting for around 2,000 of the fatalities.

Others died in villages further downstream, as well as on the opposite side of the reservoir to the landslide, where another huge wave swept up the hillside.

It is estimated that more than half those killed were never found, their bodies buried too deep to be recovered under the vast mud plain that the water left behind.  Others were carried for miles along the Piave River, some possibly into the Adriatic.

The collapse of the mountain filled in almost
half of the reservoir in minutes

A cemetery exists at Fortogna, which commemor- ates all those known to have died, although the headstones - identical blocks of marble in uniform rows - do not necessarily correspond with the remains buried immediately underneath. In many cases there are no remains at all.  To the dismay of relatives, flowers and personal memorials are not permitted to be left.

In the immediate aftermath of the disaster, the Italian government and the two authorities involved with the construction of the dam - the Adriatic Energy Corporation (Societa Adriatica di Elettrica) and, at a later stage, the National Entity for Electricity (Ente nazionale per l'energia elettrica) - attributed the catastrophe to natural causes. Journalists who suggested otherwise were accused of "undermining public order".

Later, however, it emerged that many warnings about the instability of the site chosen had been ignored and the project had been allowed to continue despite a number of landslides over a period of four years before the disaster.

A number of engineers eventually went on trial and some were convicted of negligence but the sentences handed out were seen by many as too lenient.  The government was urged to sue the Adriatic Energy Corporation for compensation but in the end decided against it.

Among events held to commemorate the 50th anniversary of the disaster in 2013, a stage of the Giro d'Italia cycle race finished in the municipality of Erto e Casso on the northern side of the reservoir, with the next stage starting in Longarone.

Longarone was completely rebuilt as a modern village

Travel tip:

Nowadays, the largely undamaged Vajont Dam - itself a triumph of engineering, at 262m (860ft) the tallest in the world at the time of construction - is open to the public and a small memorial chapel has been built.  The rebuilt village of Longarone contains a memorial church designed by one of Italy's most influential 20th century architects, Giovanni Michelucci.

Travel tip:

The most important city in the upper Piave valley, situated about 30km south of Longarone, is Belluno, a former Alpine Town of the Year, where there has been a settlement of some kind since around 220BC.  Subsequently it passed into the hands of the Romans.  The sarcophagus of Caius Flavius Hosilius and his wife Domitia can be found in the church of Santo Stefano, which was built on the site of a Roman cemetery.

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